Skip to main content
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1977 Jan;5(1):75–80. doi: 10.1128/jcm.5.1.75-80.1977

Cardiobacterium hominis endocarditis: description of two patients and characterization of the organism.

D D Savage, R L Kagan, N A Young, A E Horvath
PMCID: PMC274535  PMID: 833269

Abstract

Two cases of endocarditis caused by Cardiobacterium hominis are reported. In both instances infection was subacute and characterized by (i) implantation on abnormal valves, (ii) chronic course lasting weeks to months before recognition, and (iii) rapid clinical and bacteriological response to penicillin, as well as other antibiotics commonly used to treat infections caused by gram-negative bacilli. Our isolates of C. hominis are compared with strains in the National Institutes of Health culture collection. Optimal growth requires yeast extract and incubation at 37 degrees C with increased humidity and supplemental CO2. The production of indole, a positive oxidase reaction, and characteristic sugar fermentation distinguish C. hominis from other slow-growing, gram-negative bacilli.

Full text

PDF
75

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARILE M. F., YAGUCHI R., EVELAND W. C. A simplified medium for the cultivation of pleuropneumonia-like organisms and the L-forms of bacteria. Am J Clin Pathol. 1958 Aug;30(2):171–176. doi: 10.1093/ajcp/30.2_ts.171. [DOI] [PubMed] [Google Scholar]
  2. Brooks G. F., O'Donoghue J. M., Rissing J. P., Soapes K., Smith J. W. Eikenella corrodens, a recently recognized pathogen: infections in medical-surgical patients and in association with methylphenidate abuse. Medicine (Baltimore) 1974 Sep;53(5):325–342. [PubMed] [Google Scholar]
  3. Dorff G. J., Jackson L. J., Rytel M. W. Infections with Eikenella corrodens. A newly recognized human pathogen. Ann Intern Med. 1974 Mar;80(3):305–309. doi: 10.7326/0003-4819-80-3-305. [DOI] [PubMed] [Google Scholar]
  4. MacLowry J. D., Jaqua M. J., Selepak S. T. Detailed methodology and implementation of a semiautomated serial dilution microtechnique for antimicrobial susceptibility testing. Appl Microbiol. 1970 Jul;20(1):46–53. doi: 10.1128/am.20.1.46-53.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Midgley J., LaPage S. P., Jenkins B. A., Barrow G. I., Roberts M. E., Buck A. G. Cardiobacterium hominis endocarditis. J Med Microbiol. 1970 Feb;3(1):91–98. doi: 10.1099/00222615-3-1-91. [DOI] [PubMed] [Google Scholar]
  6. Morrow A. G., Roberts W. C., Ross J., Jr, Fisher R. D., Behrendt D. M., Mason D. T., Braunwald E. Obstruction to left ventricular outflow. Current concepts of management and operative treatment. Ann Intern Med. 1968 Dec;69(6):1255–1286. doi: 10.7326/0003-4819-69-6-1255. [DOI] [PubMed] [Google Scholar]
  7. Perdue G. D., Dorney E. R., Ferrier F. Embolomycotic aneurysm associated with bacterial endocarditis due to Cardiobacterium hominis. Am Surg. 1968 Dec;34(12):901–904. [PubMed] [Google Scholar]
  8. Roberts W. C., Perloff J. K. Mitral valvular disease. A clinicopathologic survey of the conditions causing the mitral valve to function abnormally. Ann Intern Med. 1972 Dec;77(6):939–975. doi: 10.7326/0003-4819-77-6-939. [DOI] [PubMed] [Google Scholar]
  9. SLOTNICK I. J., DOUGHERTY M. FURTHER CHARACTERIZATION OF AN UNCLASSIFIED GROUP OF BACTERIA CAUSING ENDOCARDITIS IN MAN: CARDIOBACTERIUM HOMINIS GEN. ET SP. N. Antonie Van Leeuwenhoek. 1964;30:261–272. doi: 10.1007/BF02046732. [DOI] [PubMed] [Google Scholar]
  10. Snyder A. I., Ellner P. D. Cardiobacterium hominis endocarditis. N Y State J Med. 1969 Mar 1;69(5):704–705. [PubMed] [Google Scholar]
  11. TUCKER D. N., SLOTNICK I. J., KING E. O., TYNES B., NICHOLSON J., CREVASSE L. Endocarditis caused by a Pasteurella-like organism; report of four cases. N Engl J Med. 1962 Nov 1;267:913–916. doi: 10.1056/NEJM196211012671804. [DOI] [PubMed] [Google Scholar]
  12. Wang K., Gobel F. L., Gleason D. F. Bacterial endocarditis in idiopathic hypertrophic subaortic stenosis. Am Heart J. 1975 Mar;89(3):359–365. doi: 10.1016/0002-8703(75)90086-1. [DOI] [PubMed] [Google Scholar]
  13. Weiner M., Werthamer S. Cardiobacterium homonis endocarditis. Characterization of the unusual organisms and review of the literature. Am J Clin Pathol. 1975 Jan;63(1):131–134. doi: 10.1093/ajcp/63.3.131. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES