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. 1977 Feb;5(2):131–136. doi: 10.1128/jcm.5.2.131-136.1977

Continuous aerosol therapy system using a modified Collison nebulizer.

H W Young, J W Dominik, J S Walker, E W Larson
PMCID: PMC274552  PMID: 845243

Abstract

A Collison nebulizer was incorporated into an exposure system for administering antiviral compounds as continuous aerosols to mice infected with influenza virus. The nebulizer was modified to control aerosol output by varying the liquid feed rate. A multiple regression equation was developed from data obtained with uranine dye to define the aerosol concentration of the dye in the system as a function of the concentration of the dye in the spray fluid and the rate at which it was aerosolized. The rate of change of the concentration of the test solution due to evaporative losses was also ascertained for a 1-ml/min feed rate over a 23.5-h period of operation. Procedures are outlined for using these relationships to determine the concentration of a given drug that will result in a given dose. Performance data for the drug ribavirin are presented.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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