Table 5.

Risk of incident fracture in women according to exposure to fluoride in drinking water

	Age adjusted*			Multivariable adjusted*†
	Relative risk (95% CI)	P value		Relative risk (95% CI)	P value
All non-vertebral fractures
Mixed exposure	1.12 (0.96 to 1.32)	0.147		1.03 (0.87 to 1.22)	0.733
Continuous exposure	1.04 (0.92 to 1.19)	0.410		0.96 (0.83 to 1.10)	0.536
Spine
Mixed exposure	0.78 (0.55 to 1.10)	0.152		0.73 (0.50 to 1.06)	0.096
Continuous exposure	0.79 (0.61 to 1.03)	0.079		0.73 (0.55 to 0.97)	0.033
Hip
Mixed exposure	0.97 (0.67 to 1.39)	0.858		0.73 (0.49 to 1.09)	0.126
Continuous exposure	0.85 (0.63 to 1.14)	0.287		0.69 (0.50 to 0.96)	0.028
Humerus
Mixed exposure	1.09 (0.73 to 1.61)	0.677		1.03 (0.67 to 1.57)	0.906
Continuous exposure	0.89 (0.64 to 1.24)	0.491		0.85 (0.58 to 1.23)	0.378
Wrist
Mixed exposure	1.11 (1.52 to 0.81)	0.514		1.09 (0.78 to 1.52)	0.628
Continuous exposure	1.36 (1.07 to 1.73)	0.012		1.32 (1.00 to 1.71)	0.051

^*Reference group: women with no exposure. 

^†Adjusted for age, weight, education, muscle strength, surgical menopause, calcium intake, drinks/week, current oestrogen use, current thiazide use, non-insulin dependent diabetes, current thyroid hormone use, walking for exercise, and smoking status.