Table 1.
Reproducibility of [11C]NPA total distribution volume (Vt, mL cm-3), binding potential relative to plasma concentrations (BPp, mL cm-3) and binding potential relative to non specific uptake (BPnd, unitless) derived via kinetic analysis (2 TC)
| VT (mL cm-3) | BPP (mL cm-3) | BPND | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subdivision | Region | Mean | (BSSD CV) | (WSSD CV) | VAR + SD | ICC | Mean | (BSSD CV) | (WSSD CV) | VAR + SD | ICC | Mean | (BSSD CV) | (WSSD CV) | VAR + SD | ICC |
| Cerebellum | 4.03 | (0.06) | (0.04) | 6% ± 4% | 0.52 | - | - | - | - | - | - | - | - | - | - | |
| LST | VST | 7.26 | (0.15) | (0.05) | 7% ± 7% | 0.78 | 3.23 | (0.30) | (0.08) | 9% ± 9% | 0.87 | 0.80 | (0.28) | 0.04 | 5% ± 5% | 0.95 |
| AST | 7.35 | (0.14) | (0.04) | 8% ± 3% | 0.83 | 3.32 | (0.28) | (0.06) | 10% ± 3% | 0.92 | 0.82 | (0.26) | 0.03 | 5% ± 4% | 0.97 | |
| Pre-DCA | 7.10 | (0.13) | (0.04) | 7% ± 3% | 0.82 | 3.07 | (0.26) | (0.06) | 8% ± 6% | 0.91 | 0.76 | (0.24) | 0.04 | 7% ± 4% | 0.94 | |
| Pre-DPU | 8.21 | (0.15) | (0.05) | 9% ± 5% | 0.80 | 4.18 | (0.28) | (0.07) | 12% ± 7% | 0.88 | 1.04 | (0.26) | 0.04 | 8% ± 5% | 0.95 | |
| Post-CA | 6.31 | (0.11) | (0.04) | 7% ± 5% | 0.73 | 2.28 | (0.26) | (0.08) | 12% ± 7% | 0.85 | 0.56 | (0.25) | 0.06 | 10% ± 9% | 0.88 | |
| SMST | Post-PU | 8.40 | (0.13) | (0.06) | 9% ± 5% | 0.78 | 4.36 | (0.22) | (0.08) | 12% ± 6% | 0.78 | 1.08 | (0.19) | 0.04 | 6% ± 4% | 0.91 |
| STR | 7.61 | (0.14) | (0.05) | 8% ± 4% | 0.79 | 3.58 | (0.25) | (0.06) | 10% ± 4% | 0.89 | 0.89 | (0.23) | 0.03 | 4% ± 3% | 0.98 | |
Values are the mean of 6 subjects with each value measured twice. BSSD CV = between subject standard deviation coefficient of variation, WSSD CV = within subject standard deviation coefficient of variation, VAR = test/retest variation, ICC = intraclass correlation coefficient.