Skip to main content
NCBI home page
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1978 Apr;7(4):394–395. doi: 10.1128/jcm.7.4.394-395.1978

Incidence and significance of hepatitis B e antigen and antibody in postnecrotic cirrhosis and primary hepatocellular carcinoma.

P Coursaget, P Maupas, A Goudeau, J Drucker
PMCID: PMC274975  PMID: 211144

Abstract

A study of the serological markers of Hepatitis B virus (HBV) including e antigen (HBe Ag) and antibody against HBe Ag (anti-HBe) was performed in Senegalese patients suffering from cirrhosis and primary hepatocellular carcinoma, and in a control group (blood donors). It was not possible to diagnose additional HBV infections in primary hepatocellular carcinoma patients using HBe Ag or anti-HBe Ab alone as serological markers. The lower prevalence of HBe Ag among primary hepatocellular carcinoma patients as compared with cirrhotic patients suggests that active replication of HBV becomes increasingly defective during the course of the malignant process.

Full text

PDF
394

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. El Sheikh N., Woolf I. L., Galbraith R. M., Eddleston A. L., Dymock I. W., Williams R. e Antigen-antibody system as indicator of liver damage in patients with hepatitis-B antigen. Br Med J. 1975 Nov 1;4(5991):252–253. doi: 10.1136/bmj.4.5991.252. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Eleftheriou N., Thomas H. C., Heathcote J., Sherlock S. Incidence and clinical significance of e antigen and antibody in acute and chronic liver disease. Lancet. 1975 Dec 13;2(7946):1171–1173. doi: 10.1016/s0140-6736(75)92657-4. [DOI] [PubMed] [Google Scholar]
  3. Feinman S. V., Berris B., Sinclair J. C., Wrobel D. M., Murphy B. L., Maynard J. E. e antigen and anti-e in HBsAg carriers. Lancet. 1975 Dec 13;2(7946):1173–1174. doi: 10.1016/s0140-6736(75)92658-6. [DOI] [PubMed] [Google Scholar]
  4. Hoofnagle J. H., Gerety R. J., Barker L. F. Antibody to hepatitis-B-virus core in man. Lancet. 1973 Oct 20;2(7834):869–873. doi: 10.1016/s0140-6736(73)92004-7. [DOI] [PubMed] [Google Scholar]
  5. Magnius L. O., Espmark J. A. New specificities in Australia antigen positive sera distinct from the Le Bouvier determinants. J Immunol. 1972 Nov;109(5):1017–1021. [PubMed] [Google Scholar]
  6. Magnius L. O., Lindholm A., Lundin P., Iwarson S. A new antigen-antibody system. Clinical significance in long-term carriers of hepatitis B surface antigen. JAMA. 1975 Jan 27;231(4):356–359. doi: 10.1001/jama.231.4.356. [DOI] [PubMed] [Google Scholar]
  7. Maupas P., Coursaget P., Goudeau A., Drucker J., Sankale M., Linhard J., Diebolt G. Virus de l'hépatite B et cancer primitif du foie: relation entre hépatite B, cirrhose et cancer primitif du foie. Ann Microbiol (Paris) 1977 Feb-Mar;128(2):245–253. [PubMed] [Google Scholar]
  8. Maupas P., Werner B., Larouzé B., Millman I., London W. T., O'Connell A., Blumberg B. S. Antibody to hepatitis-B core antigen in patients with primary hepatic carcinoma. Lancet. 1975 Jul 5;2(7923):9–11. doi: 10.1016/s0140-6736(75)92951-7. [DOI] [PubMed] [Google Scholar]
  9. Nielsen J. O., Dietrichson O., Juhl E. Incidence and meaning of the "e" determinant among hepatitis-B-antigen positive patients with acute and chronic liver diseases. Report from the Copenhagen Hepatitis Acuta Programme. Lancet. 1974 Oct 19;2(7886):913–915. doi: 10.1016/s0140-6736(74)91127-1. [DOI] [PubMed] [Google Scholar]
  10. Nordenfelt E., Kjellén L. Dane particles, DNA polymerase, and e-antigen in two different categories of hepatitis B antigen carriers. Intervirology. 1975;5(3-4):225–232. doi: 10.1159/000149918. [DOI] [PubMed] [Google Scholar]
  11. Ohbayashi A., Matsuo Y., Mozai T., Imai M., Mayumi M. Letter: Decreasing frequency of e antigen with age in serum of symptom-free carriers of hepatitis B antigen. Lancet. 1976 Sep 11;2(7985):577–578. doi: 10.1016/s0140-6736(76)91829-8. [DOI] [PubMed] [Google Scholar]
  12. Okada K., Kamiyama I., Inomata M., Imai M., Miyakawa Y. e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. N Engl J Med. 1976 Apr 1;294(14):746–749. doi: 10.1056/NEJM197604012941402. [DOI] [PubMed] [Google Scholar]
  13. Tabor E., Gerety R. J., Vogel C. L., Bayley A. C., Anthony P. P., Chan C. H., Barker L. F. Hepatitis B virus infection and primary hepatocellular carcinoma. J Natl Cancer Inst. 1977 May;58(5):1197–1200. doi: 10.1093/jnci/58.5.1197. [DOI] [PubMed] [Google Scholar]
  14. Thamer G., Gmelin K., Kommerell B. Letter: E antigen: prognostic marker in acute viral hepatitis B? Lancet. 1976 Sep 11;2(7985):577–577. doi: 10.1016/s0140-6736(76)91828-6. [DOI] [PubMed] [Google Scholar]
  15. Vogel C. L., Anthony P. P., Mody N., Barker L. F. Hepatitis-associated antigen in Ugandan patients with hepatocellular carcinoma. Lancet. 1970 Sep 26;2(7674):621–624. doi: 10.1016/s0140-6736(70)91396-6. [DOI] [PubMed] [Google Scholar]
  16. Werner B. G., Murphy B. L., Maynard J. E., Larouzé B. Anti-e in primary hepatic carcinoma. Lancet. 1976 Mar 27;1(7961):696–696. doi: 10.1016/s0140-6736(76)92813-0. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES