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. Author manuscript; available in PMC: 2009 Sep 23.
Published in final edited form as: Biochemistry. 2008 Jun 24;47(25):6711–6718. doi: 10.1021/bi800117f

Figure 1.

Figure 1

The effect of urea and sorbitol on HPC osmotic stress force curves at 20 °C. The PEG osmotic pressure dependence of the spacing between HPC chains determined from the Bragg scattering peak is shown for HPC in water, in 0.5 and 1 m urea, and in 0.5 and 1 m sorbitol. Urea has no effect on HPC forces, while intermolecular spacings are significantly closer in sorbitol at the same PEG osmotic pressure. The arrow illustrates the apparent excess osmotic pressure, Πexcess, exerted by 1 m sorbitol at ~ 15.5 Å.