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. Author manuscript; available in PMC: 2009 Sep 23.
Published in final edited form as: Biochemistry. 2008 Jun 24;47(25):6711–6718. doi: 10.1021/bi800117f

Table 3.

Free energies, enthalpies and entropies of osmolyte exclusion at 20 °C

Osmolyte ΔG, cal/mol/osm ΔH, cal/mol/osm −TΔS, cal/mol/osm
Glycerol 100 2300 −2200
Sorbitol 200 2650 −2450
TMAO 150 600 −350
Proline 200 1700 −1500
Glycine Betaine 220 1400 −1180

The thermodynamic parameters are calculated for 20 °C per mole glucose monomer. The error in ΔG is ~15%. The errors for ΔH and −TΔS values are ~30%