Table 3.

Association of Plasma ADMA and brain MRI variables

	Large WMH		Silent Brain Infarct
Model	Odds Ratio (95% CI)	p	Odds Ratio (95% CI)	p
Model 1*
1 SD ↑	1.00 [0.87–1.14	1.00	1.15 [1.00–1.32]	0.04
Q1		Ref		Ref
Q2	0.98 [0.67–1.43]	0.90	1.54 [1.02–2.34]	0.04
Q3	1.13 [0.78–1.63]	0.52	1.34 [0.88–2.05]	0.17
Q4	0.96 [0.66–1.40]	0.82	1.49 [0.98–2.26]	0.07
Trend across quartiles		0.98		0.06
Q234 vs. Q1	1.02 [0.75–1.39]	0.90	1.46 [1.02–2.07]	0.04
Model 2†
1 SD ↑	1.00 [0.87–1.14]	0.95	1.16 [1.01–1.33]	0.04
Q1		Ref		Ref
Q2	0.98 [0.67–1.44]	0.92	1.56 [1.03–2.37]	0.04
Q3	1.09 [0.76–1.59]	0.63	1.26 [0.82–1.94]	0.28
Q4	0.95 [0.65–1.39]	0.80	1.49 [0.98–2.27]	0.06
Trend across quartiles		0.95		0.16
Q234 vs. Q1	1.01 [0.74–1.37]	0.95	1.43 [1.00–2.04]	0.05
Model 3‡
1 SD ↑	1.00 [0.87–1.14]	0.97	1.15 [1.00–1.33]	0.05
Q1		Ref		Ref
Q2	0.96 [0.66–1.41]	0.84	1.57 [1.03–2.39]	0.04
Q3	1.06[0.73–1.54]	0.76	1.24 [0.81–1.91]	0.33
Q4	0.95 [0.65–1.39]	0.81	1.48 [0.97–2.26]	0.07
Trend across quartiles		0.94		0.18
Q234 vs. Q1	0.99 [0.73–1.35]	0.95	1.43 [1.00–2.03]	0.05

^*Model 1 (adjusted for age, sex and time to MRI)

^†Model 2 (Model 1 plus additionally adjusted for atrial fibrillation, history of cardiovascular disease, smoking, diabetes mellitus, systolic blood pressure, anti-hypertension therapy)

^‡Model 3 (Model 2 plus additionally adjusted for serum creatinine)