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. 2003 Jan 9;4(1):6–17. doi: 10.1208/pt040102

Physicochemical characterization and dissolution properties of nimesulide-cyclodextrin binary systems

Buchi N Nalluri 1,✉, K P R Chowdary 1, K V R Murthy 1, A R Hayman 2, G Becket 3
PMCID: PMC2750298  PMID: 12916912

Abstract

The objective of this work is physicochemical characterization of nimesulide-cyclodextrin binary systems both in solution and solid state and to improve the dissolution properties of nimesulide (N) via complexation with α-, β, and γ-cyclodextrins (CDs). Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1H nuclear magnetic resonance (1H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro dissolution studies. Phase solubility, mass spectrometry and 1H-NMR studies in solution revealed 1∶1 M complexation of N with all CDs. A true inclusion of N with β-CD at 1∶2 M in solid state was confirmed by DSC, powder X-RD and SEM studies. Dissolution properties of N-CD binary systems were superior when compared to pure N.

Keywords: nimesulide, cyclodextrins, physicochemical characterization, dissolution properties

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