Conclusions
The findings of this investigation thus conclusively demonstrate the promising role of concomitant therapy of liposomal TRE and BP gels in treating acne patients. Allthough their use improved the therapeutic response, more benefits of the liposomal form of drugs were observed in terms of reduction in adverse effects of therapy, thus fostering better patient compliance. It can be concluded that this study underscores the potential utility of concomitant therapy with liposomal TRE and BP gels in the treatment of acne. However, the role of liposmal formulations may only be established after clinical evaluation of alarge number of patients, with a special focus on the adverse symptoms of therapy.
KeyWords: Liposome, tretinoin, benzoyl peroxide, acne
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References
- 1.Cohen BA, Prose N, Schachner LA. Acne. In: Schachner LA, Hansen RC, editors. Pediatric Dermatology. Vol. I. New York: Churchill Livingstone; 1988. pp. 663–694. [Google Scholar]
- 2.Reynolds JEF, editor. Martindale:The Extra Pharmacopoeia. 31st ed. London: Royal Pharmaceutical Society; 1996. pp. 1077–1077. [Google Scholar]
- 3.Mezei M. Liposomes and the skin. In: Gregoriadis G, Florence AT, Patel H, editors. Liposomes in Drug Delivery. Switzerland: Harwood Academic Publishers; 1993. pp. 124–135. [Google Scholar]
- 4.Touitou E, Junginger HE, Weiner ND, Nagai T, Mezei M. Liposomes as carriers for topical and transdermal delivery. J Pharm Sci. 1994;83:1189–1203. doi: 10.1002/jps.2600830902. [DOI] [PubMed] [Google Scholar]
- 5.Hsiu-Ying Y, Hui-Min L. Triamcinolone permeation from different liposome formulations through rat skin in vitro. Int J Pharm. 1996;127:1–7. doi: 10.1016/0378-5173(95)04055-2. [DOI] [Google Scholar]
- 6.Kim MK, Chung SJ, Lee MH, Cho AR, Shim CK. Targeted and sustained delivery of hydrocortisone to normal and stratum comeum removed skin without enhanced skin absorption using a liposome gel. J. Control Release. 1997;46:243–251. doi: 10.1016/S0168-3659(96)01604-5. [DOI] [Google Scholar]
- 7.Fresta M, Puglisi G. Corticosteroid dermal delivery with skin-lipid liposomes. J Control Release. 1997;44:141–151. doi: 10.1016/S0168-3659(96)01519-2. [DOI] [Google Scholar]
- 8.Trafny EA, Antos-Bielska M, Grzybowski J. Antibacterial activity of liposome encapsulated antibiotic against Pseudomonas aeruginosa attached to the matrix of human dermis. J Microencap. 1999;16:419–429. doi: 10.1080/026520499288889. [DOI] [PubMed] [Google Scholar]
- 9.Skalko N, Cajkovac M, Jalsenjak I. Liposomes with clindamycin hydrochloride in the therapy of acne vulgaris. Int J Pharm. 1992;85:97–101. doi: 10.1016/0378-5173(92)90138-R. [DOI] [Google Scholar]
- 10.Patel VB, Misra AN, Marfatia YS. Topical liposomal gel of tretinoin for the treatment of acne: research and clinical implications. Pharm Dev Tech. 2000;5:455–464. doi: 10.1081/PDT-100102029. [DOI] [PubMed] [Google Scholar]
- 11.Patel VB, Misra AN, Marfatia YS. Preparation and comparative clinical evaluation of liposomal gel of benzoyl peroxide for acne. Drug Dev Ind Pharm. In press. [DOI] [PubMed]
- 12.Gennaro AR, editor. Remington: The science and practice of pharmacy. Vol. II. 19th ed. Easton, PA: Mack Publishing Co; 1995. pp. 878–879. [Google Scholar]
- 13.Korting HC, Schafer-korting M, Zienicke H, Braun-Falco O. Skin Pharmacol. 1990;3:206–206. doi: 10.1007/BF00315408. [DOI] [PubMed] [Google Scholar]
- 14.Singh R, Vyas SP. Selective drug delivery through and within skin using liposomes. Int J Pharm Sci. 1996;58:9–17. [Google Scholar]