Abstract
Serial serum samples from patients with acute pancreatitis showed a significant increase in antibodies against methanol-chloroform-extracted lipid antigen from Mycoplasma pneumoniae when tested by complement fixation. The antibodies did not react with antigens prepared from other human mycoplasmas or from pancreatic tissue by lipid extraction. The antibodies were predominantly immunoglobulin M (IgM). No correlation with cold agglutinins or cardiolipid complement-fixing antibodies was found. The IgM antibody response seemed to be prolonged: after 3 to 4 weeks the antibodies were still in many cases exclusively IgM. Similar IgM responses were also found in certain cases of acute meningoencephalitis. We postulate that during the disease antigenic components identical or very similar to major determinants in the M. pneumoniae lipid antigen are revealed and elicit the IgM antibody response. Their resemblance to natural antibodies and their possible biological role is discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- DOWDLE W. R., ROBINSON R. Q. AN INDIRECT HEMAGGLUTINATION TEST FOR DIAGNOSIS OF MYCOPLASMA PNEUMONIAE INFECTIONS. Proc Soc Exp Biol Med. 1964 Aug-Sep;116:947–950. doi: 10.3181/00379727-116-29416. [DOI] [PubMed] [Google Scholar]
- ENNY G. E., GRAYSTON J. T. EATON PLEUROPNEUMONIA-LIKE ORGANISM (MYCOPLASMA PNEUMONIAE) COMPLEMENT-FIXING ANTIGEN: EXTRACTION WITH ORGANIC SOLVENTS. J Immunol. 1965 Jul;95:19–25. [PubMed] [Google Scholar]
- Leinikki P., Pantzar P., Tykkä H. Antibody response in patients with acute pancreatitis to mycoplasma pneumoniae. Scand J Gastroenterol. 1973;8(7):631–635. [PubMed] [Google Scholar]
- Lemcke R. M., Marmion B. P., Plackett P. Immunochemical analysis of Mycoplasma pneumoniae. Ann N Y Acad Sci. 1967 Jul 28;143(1):691–702. doi: 10.1111/j.1749-6632.1967.tb27715.x. [DOI] [PubMed] [Google Scholar]
- Menonna J., Chmel H., Menegus M., Dowling P., Cook S. Precipitating antibodies in mycoplasma infection. J Clin Microbiol. 1977 Jun;5(6):610–612. doi: 10.1128/jcm.5.6.610-612.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Penttinen K., Vaheri A., Myllylä G. Detection and characterization of immune complexes by the platelet aggregation test. I. Complexes formed in vitro. Clin Exp Immunol. 1971 Mar;8(3):389–397. [PMC free article] [PubMed] [Google Scholar]
- Plackett P., Marmion B. P., Shaw E. J., Lemcke R. M. Immunochemical analysis of Mycoplasma pneumoniae. 3. Separation and chemical identification of serologically active lipids. Aust J Exp Biol Med Sci. 1969 Apr;47(2):171–195. doi: 10.1038/icb.1969.19. [DOI] [PubMed] [Google Scholar]
- Prescott B., Caldes G., James W. D., Chanock R. M. Phospholipid hapten of Mycoplasma pneumoniae. Ann N Y Acad Sci. 1967 Jul 28;143(1):497–500. doi: 10.1111/j.1749-6632.1967.tb27693.x. [DOI] [PubMed] [Google Scholar]
- Razin S., Prescott B., Caldes G., James W. D., Chanock R. M. Role of Glycolipids and Phosphatidylglycerol in the Serological Activity of Mycoplasma pneumoniae. Infect Immun. 1970 Apr;1(4):408–416. doi: 10.1128/iai.1.4.408-416.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sobeslavský O., Prescott B., James W. D., Chanock R. M. Serological and immunogenic activities of different fractions of Mycoplasma pneumoniae. Ann N Y Acad Sci. 1967 Jul 28;143(1):682–690. doi: 10.1111/j.1749-6632.1967.tb27714.x. [DOI] [PubMed] [Google Scholar]
- Taylor-Robinson D., Sobeslavsyý O., Jensen K. E., Senterfit L. B., Chanock R. M. Serologic response to Mycoplasma pneumoniae infection. I. Evaluation of immunofluorescence, complement fixation, indirect hemagglutination, and tetrazolium reduction inhibition tests for the diagnosis of infection. Am J Epidemiol. 1966 Mar;83(2):287–298. doi: 10.1093/oxfordjournals.aje.a120585. [DOI] [PubMed] [Google Scholar]