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. Author manuscript; available in PMC: 2009 Sep 28.
Published in final edited form as: Neurology. 2005 Oct 25;65(8):1227–1231. doi: 10.1212/01.wnl.0000180958.22678.91

Table 4.

Results from Cox proportional hazards models of time-to-conversion among MCIs (n=72).

One-variable models Two-variable model
Adjusted Cross-sectional volume APC Adjusted Cross-sectional volume APC
HR (95% CI) P HR (95% CI) P HR (95% CI) P HR (95% CI) P
Hippocampus 1.51 (1.1, 2.0) 0.002 1.13 (0.8, 1.5) 0.23 1.51 (1.1, 2.0) 0.003 1.06 (0.8, 1.5) 0.37
ERC 1.22 (0.9, 1.7) 0.12 1.13 (0.8, 1.5) 0.23 1.21 (0.9, 1.7) 0.14 1.10 (0.8, 1.5) 0.28
Whole brain 1.33 (0.9, 1.9) 0.05 1.37 (1.1, 1.8) 0.007 1.17 (0.8, 1.7) 0.21 1.30 (1.0, 1.7) 0.034
Ventricle 1.03 (0.8, 1.4) 0.43 1.71 (1.3, 2.3) <0.001 0.97 (0.7, 1.3) 0.58 1.72 (1.3, 2.4) <0.001

Note: There were 39 observed conversion among the MCI cohort.

Follow-up starts with second scan.

HR = Hazard Ratio for a 1-standard deviation decrease in cross-sectional volume or annual percent change in volume (except for ventricle estimate which is based on a 1-standard deviation increases).