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. 1979 Jun;9(6):693–698. doi: 10.1128/jcm.9.6.693-698.1979

Characterization of a screening test for diphtherial toxin antigen produced by individual plaques of corynebacteriophages.

S L Welkos, R K Holmes
PMCID: PMC275381  PMID: 115898

Abstract

A passive immune hemolysis assay has been developed to detect diphtherial toxin produced in individual plaques of tox+ corynebacteriophages. This assay permits rapid screening of large numbers of corynebacteriophages for their ability to code for diphtherial toxin or related antigens. The specificity of the assay and its potential usefulness for genetic studies of toxinogenesis have been demonstrated with well-characterized tox+ and tox- laboratory strains of corynebacteriophages.

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Selected References

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