Figure 5.

A, GFP-positive graft-derived cells in the host pancreas express glucagon and insulin. Serial pancreatic sections from diabetic NOD mice that received the combination treatment and were unilaterally nephrectomized at 45 d were scored for GFP fluorescence (upper panels) and then stained with antiglucagon and antiinsulin antibodies (lower panels). Bar, 100 μm. B, Endogenous islet (GFP negative, insulin positive) from the pancreas of a diabetic NOD mouse that received the combination treatment and was unilaterally nephrectomized at 45 d. Bar, 100 μm.