Figure 2.

Haplotype analysis of the MPL locus in the eight Italian HT families and one Japanese family with the MPL-S505N mutation. The chromosomal region containing the MPL gene is shown. Arrows indicate the distances of microsatellite markers from the location of the MPL mutation. Names of microsatellite markers are shown below the locus, and numbers below the markers indicate the sizes in nucleotides of the PCR products of the co-segregating mutated alleles in each of the nine families. Families in which the marker was non-informative (n.i.) are marked. The two different haplotypes in the Italian and Japanese families are highlighted in gray.