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. 1992 Apr;3(4):445–450. doi: 10.1091/mbc.3.4.445

Phosphorylation of FAR1 in response to alpha-factor: a possible requirement for cell-cycle arrest.

F Chang 1, I Herskowitz 1
PMCID: PMC275594  PMID: 1498364

Abstract

Exposure of yeast a cells to alpha-factor causes cells to arrest in the G1 phase of the cell cycle. The FAR1 gene is required for this cell-cycle arrest; its product is necessary for the inhibition of a G1 cyclin, CLN2. Earlier work demonstrated that alpha-factor caused an increase in the transcription of FAR1 severalfold over a measurable basal level. We now show that transcriptional induction of FAR1 from a heterologous promoter is not sufficient to inhibit CLN2 in the absence of alpha-factor. We also show that FAR1 is phosphorylated in response to alpha-factor and propose that this phosphorylation may be required for FAR1 activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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