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. 1993 Sep;4(9):897–906. doi: 10.1091/mbc.4.9.897

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.

H Zhang 1, Y Xiong 1, D Beach 1
PMCID: PMC275720  PMID: 7903056

Abstract

We have recently shown that two proteins, proliferating cell nuclear antigen (PCNA) and p21, are associated with cyclin D. Here we show that PCNA and p21 are common components of a wide variety of cyclin/cyclin-dependent kinase complexes in nontransformed cells. These include kinase complexes containing cyclin A, cyclin B, and cyclin D, associated either with CDC2, CDK2, CDK4, or CDK5. We show that PCNA and p21 form separate quaternary complex with each cyclin/CDK and that these quaternary complexes contain a substantial, if not major, fraction of the cell cycle kinases in asynchronously growing cells. These results suggest that PCNA and p21 may perform a common function for all these kinases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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