Table 6.
Cancer | Sex | Hazard ratio (95% CI) | Cumulative risk (95% CI) | ||
---|---|---|---|---|---|
to age 50 | to age 60 | to age 70 | |||
Colorectal | Male | 5.2 (2.8–9.7) | 2% (1%–4%) | 8% (4%–14%) | 20% (11% – 34%) |
Female | 5.2 (2.8–9.7) | 2% (1%–4%) | 6% (3%–10%) | 15% (8% – 26%) | |
Endometrial | Female | 7.5 (2.8–20.0) | 3% (1%–8%) | 9% (3%–21%) | 15% (6% – 35%) |
Less frequent Lynch cancers* | Male | 2.5 (0.4–16.2) | 1% (0%–8%) | 3% (0%–17%) | 6% (1% – 33%) |
Female | 2.5 (0.5–12.6) | 1% (0%–7%) | 3% (1%–13%) | 6% (1% – 25%) | |
Other cancers | Male | 0.9 (0.3–2.3) | 4% (1%–9%) | 10% (4%–24%) | 24% (10% – 51%) |
Female | 1.5 (0.8–3.1) | 8% (4%–15%) | 16% (8%–29%) | 27% (15% – 48%) | |
Any Lynch Syndrome-associated cancer | Male | 4% (2%–10%) | 10% (6%–24%) | 25% (16%–48%) | |
Female | 6% (4%–14%) | 16% (10%–31%) | 32% (21%–53%) |
Kidney (renal pelvis), stomach, ovary, small bowel, ureter, brain