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MMP indexing for the evaluation of endogenous brain MMP production as reflected in the cerebrospinal fluid (CSF) for time of arrival, 24, and 72 hours following TBI compared to NPH controls. (A) The MMP-9 index is statistically elevated over NPH (p<0.02) and suggests intrathecal production. (B) The index for MMP-2 is not significantly different from NPH. The data spread for MMP-2 is suggestive that some patients may have endogenous production.
