TABLE V.
Injected activity, specific activity, and mass of (S)-5-[123I]iodo-3-(2-azetidinylmethoxy)pyridine (5-[123I]IA) administered to twelve healthy adult volunteers
| Subject number | Method of administration | Activity injected in mCi | Specific activity in mCi/micromol | Mass in micrograms |
|---|---|---|---|---|
| 1 | Bolus | 8.1 | 7, 522 | 0.39 |
| 2 | Bolus | 9.1 | >33, 600 | <0.10 |
| 3 | Bolus | 9.3 | >27, 064 | <0.13 |
| 4 | Bolus | 8.8 | >29, 340 | <0.12 |
| 5 | Bolus | 8.6 | 43, 160 | 0.07 |
| 6 | Bolus followed by continuous infusion | 7.8 | 20, 815 | 0.11 |
| 7 | Bolus followed by continuous infusion | 7.6 | 16, 207 | 0.13 |
| 8 | Bolus followed by continuous infusion | 5.2 | 21, 141 | 0.07 |
| 9 | Bolus followed by continuous infusion | 8.1 | 25,948 | 0.09 |
| 10 | Bolus followed by continuous infusion | 7.7 | 10,070 | 0.003 |
| 11 | Bolus | 2.1 | 16,117 | 0.0006 |
| 12 | Bolus | 7.35 | 8400 | 0.275 |