Table 5.

Growth inhibition activity of desferridanoxamine-Lorabid® (Dan-Lor), desferridanoxamine-ciprofloxacin (Dan-Cip), and desferridanoxamine-triclosan (Dan-Tri) conjugates relative to standards desferridanoxamine (Dan), Lorabid® (Lor), ciprofloxacin (Cip), and triclosan (Tri). 50μL of each compound solution was filled in 9 mm wells in agar media (Standard I Nutrient Agar, Serva). Inhibition zones read after incubation at 37°C for 24 h (Long, T. E., manuscript in preparation).

Test Organism/Compound	Zone of Growth Inhibition (mm)
	Dan 2.0 mM	Dan-Lor 2.0 mM	Lor 2.0 mM	Dan-Cip 0.2 mM	Cip 0.2 mM	Dan-Tri 0.2 mM	Tri 0.2 mM
B. subtilis ATCC 6633	0	14c/19P	34b	26	36	21	18
S. aureus SG511	0	18/26.5P	28/34.5p	25	52	41	29
S. aureus 134/94 (MRSA)	0	0	0	0	13	25	26
M. luteus ATCC 10240	0	11/16p	38/42p	0	19	16	20
M. vaccae IMET 10670	23	20.5	0b	20	44	28	32
E. faecalis 1528 (VRE)	0	0	0b	16	24.5	15	16
E. cloacae P99	12a	nt	0	18	29	22.5	29
E. coli AB2847	17p	17p	25	20	33.5	25	31
E. coli BR158	19.5p	19p	27	15	34	25	31
E. coli H1876	20p	18p	28.5	18	27	27	32
E. coli HK 9/7	19.5p	19.5p	30	20.5	28	29	33.5
E. coli IV-3-2	20h	19h	25.5	0	27	28	33
E. coli DC 0	24h	19.5h	26	0	25.5	24.5	28.5
E. coli DC 2	20.5P	14/19P	31	16	31.5	44	50
P. aeruginosa K199	0	0	0	0	25	0	0
P. aeruginosa K648	0	0	0	0	33	0	0
P. aeruginosa IV-3-13	0	0	0	0	35	0	15P
P. aeruginosa 799/WT	0	0	0	17P	39	0	0
P. aeruginosa 799/61	0	15/23p/40h	23/27p	18	43	0	0

c = single colonies in the inhibition zone

p = partially clear inhibition zone/colonies in the inhibition zone

P = unclear inhibition zone/many colonies in the inhibition zone

h = faint indication of inhibition zone

nt = not tested

^aConcentration = 0.5 mM

^bConcentration = 0.2 mM