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. 1967 Oct;94(4):804–811. doi: 10.1128/jb.94.4.804-811.1967

In Vivo and In Vitro Manifestations of Adrenergic Blockade in Bordetella pertussis-vaccinated Mice1

Kenneth F Keller a, Charles W Fishel a
PMCID: PMC276735  PMID: 4383132

Abstract

The in vivo metabolic events which follow the administration of epinephrine, norepinephrine, or isoproterenol were examined in normal, Bordetella pertussis-vaccinated, and α and β adrenergically blocked mice. The normal hyperglycemic response to epinephrine was suppressed in all experimental groups. The pertussis-sensitized and β-blocked animals produced similar split patterns of altered response not duplicated by the α-blocking compounds. Those catecholamines that normally increase free fatty acids and lactic acid in the circulation failed to do so in the pertussis-sensitized and β-blocked animals; the inhibition of free fatty acid mobilization was also demonstrated with adipose tissue incubated in vitro. An extract of the pertussis organism added to incubation media prevented the catecholamine-induced free fatty acid response. The epinephrine-stabilizing effect of bovine serum albumin (Cohn-fraction V) was observed. The results of these studies further emphasize a correlation between pertussis-sensitized and β-adrenergically blocked mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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