Abstract
Valine coordinately increases the levels of three of the enzymes participating in the biosynthesis of isoleucine and valine in Mycobacterium pellegrino. The amount of valine required for end-product induction depends on the condition of the cells. Isoleucine inhibits the effect of valine. Acetohydroxy acid synthetase, the enzyme catalyzing the first common step in the biosynthesis of valine and isoleucine, is inhibited by valine. The induction effect of valine appears to be due to its ability to inhibit the activity of this enzyme, thus causing isoleucine deficiency, which in turn leads to derepression. This conclusion is supported by the fact that valine, under certain conditions, inhibits growth.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BAUERLE R. H., FRUENDLICH M., STORMER F. C., UMBARGER H. E. CONTROL OF ISOLEUCINE, VALINE AND LEUCINE BIOSYNTHESIS. II. ENDPRODUCT INHIBITION BY VALINE OF ACETOHYDROXY ACID SYNTHETASE IN SALMONELLA TYPHIMURIUM. Biochim Biophys Acta. 1964 Oct 23;92:142–149. [PubMed] [Google Scholar]
- HALPERN Y. S., UMBARGER H. E. Evidence for two distinct enzyme systems forming acetolactate in Aerobacter aerogenes. J Biol Chem. 1959 Dec;234:3067–3071. [PubMed] [Google Scholar]
- HORVATH I., GADO I., SZENTIRMAI A. Possible causes for production of isoleucine by Streptomyces rimosus. Nature. 1961 Nov 18;192:641–642. doi: 10.1038/192641a0. [DOI] [PubMed] [Google Scholar]
- HORVATH I., GADO I., SZENTIRMAI A. Valine and isoleucine metabolism of Streptomyces rimosus. Acta Microbiol Acad Sci Hung. 1962;9:11–22. [PubMed] [Google Scholar]
- HORVATH I., GADO I., SZENTIRMAY A. Formation of isoleucine in culture media containing threonine. J Bacteriol. 1959 Aug;78:293–293. doi: 10.1128/jb.78.2.293-293.1959. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HORVATH I., VARGA J. M., SZENTIRMAI A. CONTROL OF VALINE AND ISOLEUCINE METABOLISM IN PSEUDOMONAS AERUGINOSA AND ESCHERICHIA COLI. J Gen Microbiol. 1964 Feb;34:241–248. doi: 10.1099/00221287-34-2-241. [DOI] [PubMed] [Google Scholar]
- LEAVITT R. I., UMBARGER H. E. Isoleucine and valine metabolism in Escherichia coli. XI. Valine inhibition of the growth of Escherichia coli strain K-12. J Bacteriol. 1962 Mar;83:624–630. doi: 10.1128/jb.83.3.624-630.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- UMBARGER H. E., BROWN B. Isoleucine and valine metabolism in Escherichia coli. VIII. The formation of acetolactate. J Biol Chem. 1958 Nov;233(5):1156–1160. [PubMed] [Google Scholar]
- UMBARGER H. E. Evidence for a negative-feedback mechanism in the biosynthesis of isoleucine. Science. 1956 May 11;123(3202):848–848. doi: 10.1126/science.123.3202.848. [DOI] [PubMed] [Google Scholar]
- Varga J. M., Horvath I. Growth inhibition of Pseudomonas aeruginosa by valine. J Bacteriol. 1966 Nov;92(5):1569–1569. doi: 10.1128/jb.92.5.1569-.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Varga J. M., Horváth I. Studies on acetohydroxy acid synthetase in Pseudomonas aeruginosa. J Mol Biol. 1965 Sep;13(2):596–599. doi: 10.1016/s0022-2836(65)80121-8. [DOI] [PubMed] [Google Scholar]
- WAGNER R. P., BERGQUIST A., BARBEE T. THE SYNTHESIS IN VITRO OF VALINE AND ISOLEUCINE FROM PYRUVATE AND ALPHA-KETOBUTYRATE IN NEUROSPORA. Biochim Biophys Acta. 1965 May 4;100:444–450. doi: 10.1016/0304-4165(65)90014-0. [DOI] [PubMed] [Google Scholar]
- WIXOM R. L., SHATTON J. B., STRASSMAN M. Studies on a dehydrase in valine biosynthesis in yeast. J Biol Chem. 1960 Jan;235:128–131. [PubMed] [Google Scholar]