Abstract
The effects of chloramphenicol and p-fluorophenylalanine (p-FPA) on growth, proportion of motile cells, average rate of motility, and the chemotactic response of a methionine auxotroph of Escherichia coli K-12 were studied. Kinetic studies revealed that the inhibition of chemotaxis by p-FPA can be explained by the effect on growth, proportion of motile cells, and average rate of motility rather than a selective inhibition of chemotaxis per se. The effect of chloramphenicol on chemotaxis could not be explained in terms of these characteristics. It is concluded that low concentrations of chloramphenicol, unlike p-FPA, selectively inhibit chemotaxis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adler J. Chemotaxis in bacteria. Science. 1966 Aug 12;153(3737):708–716. doi: 10.1126/science.153.3737.708. [DOI] [PubMed] [Google Scholar]
- Adler J. Effect of amino acids and oxygen on chemotaxis in Escherichia coli. J Bacteriol. 1966 Jul;92(1):121–129. doi: 10.1128/jb.92.1.121-129.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Armstrong J. B., Adler J., Dahl M. M. Nonchemotactic mutants of Escherichia coli. J Bacteriol. 1967 Jan;93(1):390–398. doi: 10.1128/jb.93.1.390-398.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COETZEE J. N. TRANSDUCTION OF SWARMING IN PROTEUS MIRABILIS. J Gen Microbiol. 1963 Oct;33:1–7. doi: 10.1099/00221287-33-1-1. [DOI] [PubMed] [Google Scholar]
- KAISER A. D., HOGNESS D. S. The transformation of Escherichia coli with deoxyribonucleic acid isolated from bacteriophage lambda-dg. J Mol Biol. 1960 Dec;2:392–415. doi: 10.1016/s0022-2836(60)80050-2. [DOI] [PubMed] [Google Scholar]
- KERRIDGE D. The effect of inhibitors on the formation of flagella by Salmonella typhimurium. J Gen Microbiol. 1960 Dec;23:519–538. doi: 10.1099/00221287-23-3-519. [DOI] [PubMed] [Google Scholar]
- Kopp R., Müller J., Lemme R. Inhibition of Swarming of Proteus by Sodium Tetradecyl Sulfate, beta-Phenethyl Alcohol, and p-Nitrophenylglycerine. Appl Microbiol. 1966 Nov;14(6):873–878. doi: 10.1128/am.14.6.873-878.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]