FIG. 5.

Glycemia and glucose tolerance of RIP-N mice. A: Nonfasting glycemia of wild-type and RIP-N males and females was determined as described in research design and methods. B: Mice were subjected to an IPGTT to analyze their response to hyperglycemic conditions. Results correspond to the means ± SD of six independent experiments. Statistic analysis was performed for each time point between wild-type and RIP-N mice (eight comparisons). No significant differences were recorded. C: Islets from wild-type and RIP-N female mice were stimulated with low- or high-glucose concentration in the presence or in the absence of exendin-4 (see research design and methods). Insulin secretion was then determined. Results are expressed as the amount of insulin secreted normalized to the initial cellular insulin content (means ± SD of quadruplicate determinations). #No statistical differences between insulin secretion of wild-type and RIP-N islets for a given stimulation regimen (four comparisons).