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. 1967 Nov;94(5):1394–1399. doi: 10.21236/ad0819931

Experimental Irradiated Arthrospore Vaccine Against Coccidioidomycosis in Mice

James D Pulliam 1, J L Converse 1, E M Snyder 1, J R Esterly 1, E P Lowe 1
PMCID: PMC276837  PMID: 6057797

Abstract

An experimental irradiated (60Co) arthrospore vaccine against coccidioidomycosis protected approximately 75% of mice from death after an intraperitoneal challenge sufficient to kill approximately 90% of the nonimmunized control mice. Although the majority of the immunized mice became infected with Coccidioides immitis, the histologic lesions were substantially less severe than those in the nonimmunized controls, particularly in the pulmonary region. Although arthrospores irradiated with 1, 2, or 3 million roentgens lost their ability to multiply in various laboratory media (probably through interference with cell division), partial conversion to the parasitic phase (spherule) was observed after animal inoculation (rounding out of arthrospores into immature spherules, but without development of endospores). Duration of viability of these structures has yet to be determined.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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