Abstract
Seven nonencapsulated mutants of Cryptococcus neoformans were isolated from an encapsulated strain of human origin. Initially, the mutants were avirulent for mice. After several months of subculturing, six of the seven isolates reverted to the encapsulated state and possessed varying degrees of virulence. The results of these experiments suggest that a strong correlation exists between the presence of a capsule and the virulence of C. neoformans.
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- Blandamer A., Danishefsky I. Investigations on the structure of the capsular polysaccharide from Cryptococcus neoformans type B. Biochim Biophys Acta. 1966 Apr 25;117(2):305–313. doi: 10.1016/0304-4165(66)90081-x. [DOI] [PubMed] [Google Scholar]
- DROUHET E., SEGRETAIN G., AUBERT J. P. Polyoside capsulaire d'un champignon pathogene Torulopsis neoformans; relation avec la virulence. Ann Inst Pasteur (Paris) 1950 Dec;79(6):891–900. [PubMed] [Google Scholar]
- HASENCLEVER H. F., MITCHELL W. O. Virulence and growth rates of Cryptococcus neoformans in mice. Ann N Y Acad Sci. 1960 Aug 27;89:156–162. doi: 10.1111/j.1749-6632.1960.tb20138.x. [DOI] [PubMed] [Google Scholar]
- KAO C. J., SCHWARZ J. The isolation of Cryptococcus neoformans from pigeon nests; with remarks on the identification of virulent cryptococci. Am J Clin Pathol. 1957 Jun;27(6):652–663. doi: 10.1093/ajcp/27.6.652. [DOI] [PubMed] [Google Scholar]
- KASE A., METZGER J. F. Isolation of a dry variant from a mucoid strain of Cryptococcus neoformas and preliminary comparative studies. J Bacteriol. 1962 Apr;83:926–928. doi: 10.1128/jb.83.4.926-928.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LITTMAN M. L., TSUBURA E. Effect of degree of encapsulation upon virulence of Cryptococcus neoformans. Proc Soc Exp Biol Med. 1959 Aug-Sep;101:773–777. doi: 10.3181/00379727-101-25090. [DOI] [PubMed] [Google Scholar]