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. 1967 Nov;94(5):1565–1581. doi: 10.1128/jb.94.5.1565-1581.1967

Neuraminidase of Corynebacterium diphtheriae

Takafumi Moriyama a,1, Lane Barksdale a
PMCID: PMC276865  PMID: 4964482

Abstract

Neuraminidase activity has been found in a variety of strains of Corynebacterium diphtheriae, both toxinogenic and nontoxinogenic. The enzyme has been shown to be intracellular, possibly associated with the cytoplasmic membrane. Toxinogenic strains of the diphtheria bacillus, grown under conditions unsuitable for maximal toxin production, produce neuraminidase, and the enzyme has been purified from cells of the Park Williams no. 8 strain grown under such conditions. Diphtherial toxin and diphtherial neuraminidase have similar molecular weights and remain associated during column chromatography; immunochemically, and in their electrophoretic behavior, they appear distinct.

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Selected References

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