Abstract
Skin hypersensitivity to streptococcal antigens was demonstrated in 15 New Zealand red rabbits that were sensitized by intracutaneous injections with group A streptococci, and leukocytic hypersensitivity, as determined by in vitro inhibition of leukocyte migration, was demonstrated in 11 of the rabbits. The skin hypersensitivity persisted for at least 8 weeks, whereas the leukocytic hypersensitivity generally waned rather rapidly. The leukocytic hypersensitivity reappeared in the infected rabbits that had developed this hypersensitivity. However, it did not reappear on reimmunization with living streptococci of the type originally employed, whereas it did reappear with living but not heat-killed streptococci of another M type.
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- BECKER C. G. SELECTION OF GROUP A STREPTOCOCCI RICH IN M-PROTEIN FROM POPULATIONS POOR IN M-PROTEIN. Am J Pathol. 1964 Jan;44:51–60. [PMC free article] [PubMed] [Google Scholar]
- CARPENTER R. R. IN VITRO STUDIES OF CELLULAR HYPERSENSITIVITY. I. SPECIFIC INHIBITION OF MIGRATION OF CELLS FROM ADJUVANT-IMMUNIZED ANIMALS BY PURIFIED PROTEIN DERIVATIVE AND OTHER PROTEIN ANTIGENS. J Immunol. 1963 Dec;91:803–818. [PubMed] [Google Scholar]
- GERLACH E. H., SCHERAGO M., HALL H. E. The effect of chemotherapy on the tuberculin sensitivity of leukocytes from tuberculous patients. Am Rev Respir Dis. 1960 Jan;81:100–101. doi: 10.1164/arrd.1960.81.1.100. [DOI] [PubMed] [Google Scholar]
- HALBERT S. P., SWICK L., SONN C. The use of precipitin analysis in agar for the study of human streptococcal infections. I. Oudin technic. J Exp Med. 1955 May 1;101(5):539–556. doi: 10.1084/jem.101.5.539. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HALL H. E., SCHERAGO M. The effect of chemotherapy on the leukocytic sensitivity to tuberculin in guinea pigs experimentally infected with Mycobacterium tuberculosis H37RV. Am Rev Tuberc. 1958 May;77(5):815–822. doi: 10.1164/artpd.1958.77.5.815. [DOI] [PubMed] [Google Scholar]
- HALL H. E., SCHERAGO M. The sensitivity of human leukocytes to old tuberculin. Am Rev Tuberc. 1957 May;75(5):807–822. doi: 10.1164/artpd.1957.75.5.807. [DOI] [PubMed] [Google Scholar]
- JOHNSON R. W., SCHERAGO M. The effect of PPD on the in vitro migration of leukocytes from guinea pigs passively sensitized to OT. Am Rev Respir Dis. 1963 May;87:739–747. doi: 10.1164/arrd.1963.87.5.739. [DOI] [PubMed] [Google Scholar]
- Kuttner A. G., Lenert T. F. THE OCCURRENCE OF BACTERIOSTATIC PROPERTIES IN THE BLOOD OF PATIENTS AFTER RECOVERY FROM STREPTOCOCCAL PHARYNGITIS. J Clin Invest. 1944 Mar;23(2):151–161. doi: 10.1172/JCI101478. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LANCEFIELD R. C. Current knowledge of type-specific M antigens of group A streptococci. J Immunol. 1962 Sep;89:307–313. [PubMed] [Google Scholar]
- NAJARIAN J. S., FELDMAN J. D. Passive transfer of tuberculin sensitivity by tritiated thymidine-labeled lymphoid cells. J Exp Med. 1961 Nov 1;114:779–790. doi: 10.1084/jem.114.5.779. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NAJARIAN J. S., FELDMAN J. D. SPECIFICITY OF PASSIVELY TRANSFERRED DELAYED HYPERSENSITIVITY. J Exp Med. 1963 Sep 1;118:341–352. doi: 10.1084/jem.118.3.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STOLLERMAN G. H., EKSTEDT R. D., COHEN I. R. NATURAL RESISTANCE OF GERM-FREE MICE AND COLOSTRUM-DEPRIVED PIGLETS TO GROUP A STREPTOCOCCI. J Immunol. 1965 Jul;95:131–140. [PubMed] [Google Scholar]