Table 3.
Association of Asthma on Obesity (as Defined by BMI Category) After Adjusting for Plasma F2-Isoprostane Concentration
| Men (n = 1,273) |
Women (n = 1,592) |
|||
|---|---|---|---|---|
| BMI Model | OR (95% CI) | p Value | OR (95% CI) | p Value |
| Adjusted for covariates | ||||
| Normal weight | 1.0 | 0.20 | 1.0 | 0.03 |
| Overweight | 0.63 (0.35–1.11) | 1.31 (0.81–2.11) | ||
| Obese | 0.62 (0.34–1.15) | 1.79 (1.16–2.76) | ||
| Adjusted for plasma isoprostanes and covariates | ||||
| Normal weight | 1.0 | 0.15 | 1.0 | 0.03 |
| Overweight | 0.62 (0.35–1.10) | 1.32 (0.81–2.13) | ||
| Obese | 0.57 (0.30–1.07) | 1.81 (1.15–2.87) | ||
All measurements were done at the same time at the year-20 evaluation. Covariates adjusted include age, race, and smoking. BMI was studied in the following three categories: normal weight (BMI < 25 kg/m2), overweight (BMI 25 to < 30 kg/m2), and obese (BMI ≥ 30 kg/m2). Twenty-five underweight (BMI < 18.5 kg/m2) subjects were included in the normal-weight category. There was a significant interaction between gender and the BMI category on asthma (p = 0.01) after adjustment for covariates. Similar results were obtained when BMI was studied as a continuous variable and when analysis was redone after excluding underweight subjects.