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. 1964 May;87(5):977–987. doi: 10.1128/jb.87.5.977-987.1964

ROLE OF RIBONUCLEIC ACID BIOSYNTHESIS IN MULTIPLICATION OF TYPE 5 ADENOVIRUS

John F Flanagan a,1, Harold S Ginsberg a
PMCID: PMC277134  PMID: 5874548

Abstract

Flanagan, John F. (University of Pennsylvania, Philadelphia), and Harold S. Ginsberg. Role of ribonucleic acid biosynthesis in multiplication of type 5 adenovirus. J. Bacteriol. 87:977–987. 1964.—The requirement for ribonucleic acid (RNA) biosynthesis in the multiplication of type 5 adenovirus was investigated by using radioactive phosphorus to label nucleic acids and two pyrimidine analogues, 6-azauridine and 5-fluorouracil or 5-fluorouridine, to inhibit synthesis of functional RNA. The data indicate that biosynthesis of RNA after infection is essential for production of virus-specific deoxyribonucleic acid, virus antigens, and infectious particles. The onset of essential RNA synthesis occurs 8 to 9 hr after virus infection and prior to the biosynthesis of other known virus-induced macromolecules.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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