Table 1.
Summary of Complementation Resultsa
| Glycoproteins | Cell Surface Expression |
Binding to gp42 |
B Cell Fusion |
Epithelial Cell Fusion |
|
|---|---|---|---|---|---|
| Rh gH | EBV gL | + | + | +b | +b |
| EBV gH | Rh gL | + | + | +/−−c | + |
| Rh gH | Rh gL | + | + | +/−−c | + |
| M gH | EBV gL | + | − | − | + |
| EBV gH | M gL | +/−−d | +/− | − | − |
| M gH | M gL | + | − | − | + |
| HHV8 gH | EBV gL | − | − | − | − |
| EBV gH | HHV8 gL | − | − | − | − |
| HHV8 gH | HHV8 gL | + | − | − | + |
a
Summary of complementation results on EBV-mediated fusion with rhesus (Rh), marmoset (M) and HHV8 gH and gL (column 3 and 4). Cell surface expression of these proteins when paired with either EBV gH or gL as well as the expression of virus specific gH/gL is shown in column 1. Both heterologous and homologous gH/gL complexes were also examined for their ability to bind to EBVgp42 (column 2).
b
Enhanced fusion, especially with epithelial cells.
c
Very low fusion, not higher than 30%, but still detectable over the background.
d
Expression lower or undetectable with the E1D1 Ab.