Abstract
Banerjee, Arun B. (University of Calcutta, Calcutta, India), and S. K. Bose. Biosynthesis of mycobacillin, a new antifungal peptide. I. Role of nucleic acid. J. Bacteriol. 87:1397–1401. 1964.—The biosynthesis of mycobacillin, a cyclic polypeptide antifungal antibiotic, was studied in relation to the effect of chloramphenicol, 6-azathymine, and 5-bromouracil on the process. It was found that chloramphenicol inhibits both mycobacillin synthesis and growth, whereas nucleic acid base analogues inhibit only growth and nucleic acid synthesis but not mycobacillin formation. A change in the concentration of labeled aspartic acid in the general metabolic pool led to a corresponding change in the specific activity of aspartic acid isolated from different peptide fragments of the mycobacillin molecule, suggesting that mycobacillin synthesis occurs by way of linear addition of amino acid to the peptide chain.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ANFINSEN C. B., STEINBERG D., VAUGHAN M. Kinetic aspects of assembly and degradation of proteins. Science. 1956 Aug 31;124(3218):389–395. doi: 10.1126/science.124.3218.389. [DOI] [PubMed] [Google Scholar]
- ASKONAS B. A., CAMPBELL P. N., GODIN C., WORK T. S. Biosynthesis of proteins. 3. Precursors in the synthesis of casein and beta-lactoglobulin. Biochem J. 1955 Sep;61(1):105–115. doi: 10.1042/bj0610105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BURTON K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J. 1956 Feb;62(2):315–323. doi: 10.1042/bj0620315. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bishop J., Leahy J., Schweet R. FORMATION OF THE PEPTIDE CHAIN OF HEMOGLOBIN. Proc Natl Acad Sci U S A. 1960 Aug;46(8):1030–1038. doi: 10.1073/pnas.46.8.1030. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DINTZIS H. M. Assembly of the peptide chains of hemoglobin. Proc Natl Acad Sci U S A. 1961 Mar 15;47:247–261. doi: 10.1073/pnas.47.3.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GALE E. F., FOLKES J. P. The assimilation of amino-acids by bacteria. XV. Actions of antibiotics on nucleic acid and protein synthesis in Staphylococcus aureus. Biochem J. 1953 Feb;53(3):493–498. doi: 10.1042/bj0530493. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MAJUMDAR S. K., BOSE S. K. Amino acid sequence in mycobacillin. Biochem J. 1960 Mar;74:596–599. doi: 10.1042/bj0740596. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MAJUMDAR S. K., BOSE S. K. Mycobacillin, a new antifungal antibiotic produced by B. subtilis. Nature. 1958 Jan 11;181(4602):134–135. doi: 10.1038/181134a0. [DOI] [PubMed] [Google Scholar]
- MAJUMDAR S. K., BOSE S. K. Utilization of amino acids by Bacillus subtilis during growth and antibiotic production. Biochim Biophys Acta. 1958 Sep;29(3):509–513. doi: 10.1016/0006-3002(58)90006-4. [DOI] [PubMed] [Google Scholar]
- SNOKE J. E., BLOCH K. Studies on the mechanism of action of glutathione synthetase. J Biol Chem. 1955 Apr;213(2):825–835. [PubMed] [Google Scholar]
- STROMINGER J. L. Biosynthesis of bacterial cell walls. Fed Proc. 1962 Jan-Feb;21:134–143. [PubMed] [Google Scholar]
- TROLL W., CANNAN R. K. A modified photometric ninhydrin method for the analysis of amino and imino acids. J Biol Chem. 1953 Feb;200(2):803–811. [PubMed] [Google Scholar]
- WINNICK R. E., LIS H., WINNICK T. Biosynthesis of gramicidin S. I. General characteristics of the process in growing cultures of Bacillus brevis. Biochim Biophys Acta. 1961 May 27;49:451–462. doi: 10.1016/0006-3002(61)90242-6. [DOI] [PubMed] [Google Scholar]
- YOSHIDA A., TOBITA T. Studies on the mechanism of protein synthesis. Nouniform incorporation of [14C]leucine into alpha-amylase and the presence of alpha-amylase precursos. Biochim Biophys Acta. 1960 Jan 29;37:513–520. doi: 10.1016/0006-3002(60)90508-4. [DOI] [PubMed] [Google Scholar]