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. Author manuscript; available in PMC: 2009 Nov 9.
Published in final edited form as: Neuroscience. 2007 Nov 12;151(1):303–312. doi: 10.1016/j.neuroscience.2007.10.037

Fig. 3.

Fig. 3

Pilocarpine induces depression of both paired pulse disynaptic responses and polysynaptic propagation of activity. (A) Stimulation of the LOT induces in the PC a response characterized by a monosynaptic component (arrow) and a disynaptic component (arrowhead). Paired-pulse depression of the dpc is dramatically enhanced in the conditioned response to LOT stimulation (40 ms pulse interval) after perfusion with 800 μM pilocarpine (middle trace). (B) Quantitative results obtained in five experiments demonstrate that pilocarpine does not change the ratio between the conditioned (mpc2) and the conditioning (mpc1) monosynaptic PC component evoked by LOT pairing at 40 ms inter-pulse interval (upper panel), while it reversibly reduces significantly (two-tailed t-test, P<0.05) the ratio between the conditioned (dpc2) and the conditioning (dpc1) disynaptic component (lower panel). Values expressed as mean±S.D. (C) Recordings from EC and CA1 during paired LOT stimuli (100 ms interpulse interval). A reduction of the disynaptic component is observed also in the EC (upper traces). In CA1 the polysynaptic response to the conditioned LOT stimulus (asterisk) is reversibly abolished.