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Journal of Bacteriology logoLink to Journal of Bacteriology
. 1965 Mar;89(3):611–616. doi: 10.1128/jb.89.3.611-616.1965

Effects of Heat on the Infecting, Antibody-Absorbing, and Interfering Powers of Vaccinia Virus

G J Galasso a,1, D G Sharp a
PMCID: PMC277510  PMID: 14273635

Abstract

Galasso, G. J. (University of North Carolina School of Medicine, Chapel Hill), and D. G. Sharp. Effects of heat on the infecting, antibody-absorbing, and interfering powers of vaccinia virus. J. Bacteriol. 89:611–616. 1965.—At 56 C the infectivity of vaccinia virus particles is destroyed rapidly, but even when it is reduced by a factor of 106 the particles are capable of producing strong interference in L cells. The rate constant K for thermal inactivation of plaque-forming power is greater than that for interfering power by the factor e3.8 or about 45 times. At 37 C both properties of the virus decline more slowly and at equal rates. The temperature coefficient of K is discontinuous in the region of 40 C, indicating quite different activation energies for the reactions above and below this critical point. The degradation of interfering power exhibits a similar discontinuity, although less in magnitude, but none has been found in the antibody-reactive power of the virus, which is much more heat resistant.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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