Abstract
Hamada, Chuya (Albert Einstein Medical Center, Philadelphia, Pa.), and Albert S. Kaplan. Kinetics of synthesis of various types of antigenic proteins in cells infected with pseudorabies virus. J. Bacteriol. 89:1328–1334. 1965.—By means of an indirect precipitation test, a determination was made of the rates of synthesis of various types of serologically specific proteins in rabbit kidney cells infected with pseudorabies virus. The rate of synthesis of cell-specific protein decreased after infection. During the early stages of the infective process, proteins which bear no precursor relationship to the viral particles (nonstructural viral proteins) and which cannot be detected in noninfected cells were formed. Almost concurrently with these nonstructural proteins, synthesis of virus precursor proteins began. The synthesis of these proteins preceded the formation of mature virus and continued until the end of the virus growth cycle.
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Selected References
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- BEN-PORAT T., KAPLAN A. S. The chemical composition of herpes simplex and pseudorabies viruses. Virology. 1962 Mar;16:261–266. doi: 10.1016/0042-6822(62)90246-5. [DOI] [PubMed] [Google Scholar]
- BENZER S. Induced synthesis of enzymes in bacteria analyzed at the cellular level. Biochim Biophys Acta. 1953 Jul;11(3):383–395. doi: 10.1016/0006-3002(53)90057-2. [DOI] [PubMed] [Google Scholar]
- Cohen S. S. GROWTH REQUIREMENTS OF BACTERIAL VIRUSES. Bacteriol Rev. 1949 Mar;13(1):1–24. doi: 10.1128/br.13.1.1-24.1949. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DARNELL J. E., Jr, LEVINTOW L. Poliovirus protein: source of amino acids and time course of synthesis. J Biol Chem. 1960 Jan;235:74–77. [PubMed] [Google Scholar]
- DULBECCO R., VOGT M. One-step growth curve of Western equine encephalomyelitis virus on chicken embryo cells grown in vitro and analysis of virus yields from single cells. J Exp Med. 1954 Feb;99(2):183–199. doi: 10.1084/jem.99.2.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
- EAGLE H. Amino acid metabolism in mammalian cell cultures. Science. 1959 Aug 21;130(3373):432–437. doi: 10.1126/science.130.3373.432. [DOI] [PubMed] [Google Scholar]
- FRANKLIN R. M., BALTIMORE D. Patterns of macromolecular synthesis in normal and virus-infected mammalian cells. Cold Spring Harb Symp Quant Biol. 1962;27:175–198. doi: 10.1101/sqb.1962.027.001.019. [DOI] [PubMed] [Google Scholar]
- GERLOFF R. K., HOYER B. H., McLAREN L. C. Precipitation of radiolabeled poliovirus with specific antibody and antiglobulin. J Immunol. 1962 Oct;89:559–570. [PubMed] [Google Scholar]
- HERSHEY A. D., DIXON J., CHASE M. Nucleic acid economy in bacteria infected with bacteriophage T2. I. Purine and pyrimidine composition. J Gen Physiol. 1953 Jul;36(6):777–789. doi: 10.1085/jgp.36.6.777. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KAPLAN A. S. A study of the herpes simplex virus-rabbit kidney cell system by the plaque technique. Virology. 1957 Dec;4(3):435–457. doi: 10.1016/0042-6822(57)90078-8. [DOI] [PubMed] [Google Scholar]
- KAPLAN A. S., VATTER A. E. A comparison of herpes simplex and pseudorabies viruses. Virology. 1959 Apr;7(4):394–407. doi: 10.1016/0042-6822(59)90068-6. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- SALZMAN N. P., LOCKART R. Z., Jr, SEBRING E. D. Alterations in HeLa cell metabolism resulting from poliovirus infection. Virology. 1959 Oct;9:244–259. doi: 10.1016/0042-6822(59)90118-7. [DOI] [PubMed] [Google Scholar]
- SCHARFF M. D., LEVINTOW L. Quantitative study of the formation of poliovirus antigens in infected HeLa cells. Virology. 1963 Apr;19:491–500. doi: 10.1016/0042-6822(63)90043-6. [DOI] [PubMed] [Google Scholar]
- SCHARFF M. D., MAIZEL J. V., Jr, LEVINTOW L. PHYSICAL AND IMMUNOLOGICAL PROPERTIES OF A SOLUBLE PRECURSOR OF THE POLIOVIRUS CAPSID. Proc Natl Acad Sci U S A. 1964 Feb;51:329–337. doi: 10.1073/pnas.51.2.329. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ZIMMERMAN E. F., HEETER M., DARNELL J. E. RNA synthesis in poliovirus-infected cells. Virology. 1963 Mar;19:400–408. doi: 10.1016/0042-6822(63)90080-1. [DOI] [PubMed] [Google Scholar]
