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. 1962 Aug;84(2):302–306. doi: 10.1128/jb.84.2.302-306.1962

ACTIVATION PHENOMENON OF CLOSTRIDIUM BOTULINUM TYPE E TOXIN

Julia Gerwing 1, Claude E Dolman 1, David A Arnott 1
PMCID: PMC277861  PMID: 13898102

Abstract

Gerwing, Julia (The University of British Columbia, Vancouver, Canada), Claude E. Dolman, and David A. Arnott. Activation phenomenon of Clostridium botulinum type E toxin. J. Bacteriol. 84:302–306. 1962—Highly purified preparations of both nonactivated and trypsin-activated type E botulinus toxins have been analyzed in an ultracentrifuge. Untreated botulinus type E toxin was found to have a sedimentation constant (S20,w) of 5.6 Svedberg units, whereas trypsin-activated toxins would not form a boundary under identical conditions. These and other considerations indicate that the mechanism of tryptic activation involves a fragmentation process whereby more toxic sites become exposed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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