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. Author manuscript; available in PMC: 2010 Oct 20.
Published in final edited form as: Biochemistry. 2009 Oct 20;48(41):9801–9809. doi: 10.1021/bi901024m

Figure 7.

Figure 7

Proposed Proton Relay in Class 2 DHODs. A small amount of the alkoxide form of Ser175 (the active site base: pKa ≥ 14 (12)) is generated by the proton relay network. The alkoxide form then deprotonates DHO in the redox reaction.