Abstract
Hasenclever, H. F. (National Institute of Allergy and Infectious Diseases, Bethesda, Md.) and W. O. Mitchell. Production of tolerance to the toxicity of Candida albicans by nonfungal materials. J. Bacteriol. 84:1325–1329. 1962.—Tolerance in mice to the toxic manifestations of viable Candida albicans cells was elicited by injections of Salmonella enteritidis or S. typhosa lipopolysaccharides, or complete Freund's adjuvant. The greatest host stimulation occurred when the lipopolysaccharides were given 1 or 6 days before intravenous challenge. The highest level of tolerance produced by intraperitoneal preinfection with C. albicans was found when the yeast cells were injected 6 days before challenge. Older mice appeared to require larger amounts of endotoxin to demonstrate toxicity tolerance. Protection in mice that received both lipopolysaccharide injections and C. albicans intraperitoneal preinfection was slightly higher than in those mice given only the individual components.
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- DUBOS R. J., SCHAEDLER R. W. Reversible changes in the susceptibility of mice to bacterial infections. I. Changes brought about by injection of pertussis vaccine or of bacterial endotoxins. J Exp Med. 1956 Jul 1;104(1):53–65. doi: 10.1084/jem.104.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FIELD T. E., HOWARD J. G., WHITBY J. L. Studies on the rapid production of a non-specific type of immunity to Salmonella typhi infection in mice. J R Army Med Corps. 1955 Oct;101(4):324–334. [PubMed] [Google Scholar]
- HASENCLEVER H. F., MITCHELL W. O. Production in mice of tolerance to the toxic manifestations of Candida albicans. J Bacteriol. 1962 Sep;84:402–409. doi: 10.1128/jb.84.3.402-409.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MOURAD S., FRIEDMAN L. Pathogenicity of Candida. J Bacteriol. 1961 Apr;81:550–556. doi: 10.1128/jb.81.4.550-556.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]