Abstract
Zygmunt, Walter A. (Mead Johnson & Co., Evansville, Ind.). Antagonism of d-cycloserine inhibition of mycobacterial growth by d-alanine. J. Bacteriol. 85:1217–1220. 1963.—Reversal of the antimycobacterial activity of d-4-amino-3-isoxazolidinone (d-cycloserine) by alanine in two species of mycobacteria actively growing on chemically defined media was compared. In both instances, d-alanine was the most effective reversal agent. The specificity with which the d isomer reversed the antimycobacterial activity of d-cycloserine was more pronounced than that observed with other species of bacteria. Mycobactin, a growth factor for certain mycobacteria, showed no reversal activity.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BONDI A., KORNBLUM J., FORTE C. Inhibition of anitbacterial activity of cycloserine by alpha-alanine. Proc Soc Exp Biol Med. 1957 Oct;96(1):270–272. doi: 10.3181/00379727-96-23452. [DOI] [PubMed] [Google Scholar]
- CUMMINS C. S., HARRIS H. Studies on the cell-wall composition and taxonomy of Actinomycetales and related groups. J Gen Microbiol. 1958 Feb;18(1):173–189. doi: 10.1099/00221287-18-1-173. [DOI] [PubMed] [Google Scholar]
- IKAWA M., SNELL E. E., LEDERER E. Occurrence of D-phenylalanine, D-allothreonine and other D-amino-acids in peptido-lipids of bacterial origin. Nature. 1960 Nov 12;188:558–560. doi: 10.1038/188558a0. [DOI] [PubMed] [Google Scholar]
- SHOCKMAN G. D. Reversal of cycloserine inhibition by D-alanine. Proc Soc Exp Biol Med. 1959 Aug-Sep;101:693–695. doi: 10.3181/00379727-101-25064. [DOI] [PubMed] [Google Scholar]
- TAKEYA K., HISATSUNE K., NAKASHIMA K. A cell-wall mucopeptide complex obtained from the culture filtrate of tubercle bacilli. Biochim Biophys Acta. 1961 Dec 23;54:595–597. doi: 10.1016/0006-3002(61)90107-x. [DOI] [PubMed] [Google Scholar]
- Zygmunt W. A. REVERSAL OF d-CYCLOSERINE INHIBITION OF BACTERIAL GROWTH BY ALANINE. J Bacteriol. 1962 Jul;84(1):154–156. doi: 10.1128/jb.84.1.154-156.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]