Table 1.
Demographic,Clinical Characteristics and CV Outcomes by Medication Group(N=519)
| No Medication (n=353) |
Anxiolytics Only (n=68) |
Antidepressants Only (n=59) |
Combined Medication (n=39) |
p value | |
|---|---|---|---|---|---|
| Age, yrs | 58.2 ± 11.2 | 57.1 ± 11.5 | 57.0 ± 10.4 | 55.5 ± 14.0 | .45 |
| BMI (kg/m2) | 29.2 ± 6.5 | 30.1 ± 6.9 | 28.9 ± 6.9 | 28.9 ± 5.1 | .70 |
| CAD severitya | 13.4 ± 13.4 | 16.0 ± 14.2 | 11.6 ± 9.5 | 12.6 ± 12.0 | .28 |
| Resting Heart Rate |
73.7 ± 11.8 | 72.3 ± 12.0 | 74.3 ± 15.8 | 71.7 ± 13.4 | .64 |
| BDI | 9 ± 7.1 | 11.3 ± 9.2 | 14.4 ± 9.6 | 15.6 ± 10.2 | <.001 |
| Trait Anxiety | 18.1 ± 5.3 | 19.9 ± 6.4 | 20.4 ± 6.4 | 22.5 ± 6.3 | <.001 |
| Ever Smoked | 167 (47%) | 41(60%) | 38 (64%) | 20 (51%) | .04 |
| Hx diabetes | 75 (21%) | 19(28%) | 17 (29%) | 9 (24%) | .42 |
| Hx hypertension |
190 (54%) | 45(66%) | 36 (61%) | 27 (69%) | .09 |
| Hx dyslipidemia |
173 (53%) | 34(52%) | 37 (63%) | 28 (74%) | .08 |
| Hx MI | 55 (16%) | 23(34%) | 11 (19%) | 11 (29%) | .003 |
| Current HRT | 134 (38%) | 28 (41%) | 33 (56%) | 18 (56%) | .02 |
| Total mortality | 25 (7.1%) | 6 (8.8%) | 8 (13.6%) | 7 (17.9%) | .07 |
| CVD events | 44 (12.5%) | 10 (14.7%) | 14 (23.7) | 13 (33.3%) | .002 |
a
CAD severity based on amount of stenosis, scores range from 0 – 100, higher scores indicate more severe stenosis; Values are means ± standard deviations or numbers of subjects (percentages). BMI=Body mass index; CAD = Coronary artery disease; HRT = Hormone replacement therapy; Hx = history of; MI = myocardial infarction; Tx = treatment.