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. 2007 Jan 30;14(1):46–51. doi: 10.1007/s00534-006-1155-8

Techniques of biliary drainage for acute cholecystitis: Tokyo Guidelines

Toshio Tsuyuguchi 1,, Tadahiro Takada 2, Yoshifumi Kawarada 3, Yuji Nimura 4, Keita Wada 2, Masato Nagino 4, Toshihiko Mayumi 5, Masahiro Yoshida 2, Fumihiko Miura 2, Atsushi Tanaka 6, Yuichi Yamashita 7, Masahiko Hirota 8, Koichi Hirata 9, Hideki Yasuda 10, Yasutoshi Kimura 9, Horst Neuhaus 11, Steven Strasberg 12, Henry Pitt 13, Jacques Belghiti 14, Giulio Belli 15, John A Windsor 16, Miin-Fu Chen 17, Sun-Whe Kim 18, Christos Dervenis 19
PMCID: PMC2784517  PMID: 17252296

Abstract

The principal management of acute cholecystitis is early cholecystectomy. However, percutaneous transhepatic gallbladder drainage (PTGBD) may be preferable for patients with moderate (grade II) or severe (grade III) acute cholecystitis. For patients with moderate (grade II) disease, PTGBD should be applied only when they do not respond to conservative treatment. For patients with severe (grade III) disease, PTGBD is recommended with intensive care. Percutaneous transhepatic gallbladder aspiration (PTGBA) is a simple alternative drainage method with fewer complications; however, its clinical usefulness has been shown only by case-series studies. To clarify the clinical value of these drainage methods, proper randomized trials should be done. This article describes techniques of drainage for acute cholecystitis.

Key words: Acute cholecystitis, Cholecystostomy, Drainage, Percutaneous, Endoscopy, Acalculous cholecystitis, Guidelines

Introduction

Biliary drainage used to be a surgical procedure consisting of external biliary drainage done under local anesthesia — called “percutaneous cholecystostomy”. With the popularization of ultrasonography, percutaneous transhepatic gallbladder drainage (PTGBD), which is an interventional procedure, has become a standard method. The usefulness of PTGBD as a drainage method for high-risk patients is endorsed by many case-series studies (level 4),18 but its superiority over conventional treatment has not been proven by randomized controlled trials (RCTs) based on the highest level of evidence (level 2b).11 Percutaneous transhepatic gallbladder aspiration (PTGBA), is an alternative biliary drainage method in which the gallbladder contents are puncture-aspirated without placing a drainage catheter. The usefulness of PTGBA has been reported only in case-series studies (level 4).3,9,10

Acalculous cholecystitis is known to occur in elderly or high-risk patients with poor systemic condition, and it can be treated by biliary drainage alone (level 4).1,2,13,14

This article describes the details of drainage procedures used for acute cholecystitis, and indicates the grades of recommendation for the procedures established by the Guidelines.

Procedures for gallbladder drainage

Percutaneous transhepatic gallbladder drainage (PTGBD)

PTGBD is an essential technique for nonoperative gallbladder drainage. After ultrasound-guided transhepatic gallbladder puncture is done with an 18-G needle, a 6- to 10-Fr pigtail catheter is placed in the gallbladder, using a guidewire under fluoroscopy (Seldinger technique; Fig. 1). The advantage of the technique is its simplicity. However, although bile aspiration and lavage are easily performed by this technique, it has disadvantages in that the drainage tube cannot be extracted until a fistula forms around the tube (around 2 weeks) and there is a risk of dislocation of the tube. The superiority of PTGBD over conservative treatment has not be proven by RCTs (level 2b)9 (Table 1).

Fig. 1a–e.

Fig. 1a–e

Percutaneous transhepatic gallbladder drainage (PTGBD) procedure. a A hollow needle (external cylinder with a mandolin) is inserted into the gallbladder. b Only the mandolin is removed and the external cylinder remains. c Backflow of bile is confirmed. d A guidewire is inserted into the gallbladder. e After removal of the external cylinder, a drainage tube is passed over the guidewire into the gallbladder. The guidewire is then withdrawn, and the tube is fixed to the skin

Table 1.

RCT comparing PTGBD and conservative treatment for high-risk acute cholecystitis (PTGBD)

n (ICUa) Symptom improvement Mortality
PTGBD group 63 (6) 86% 17.5%
Conservative treatment 60 (2) 87% 13% NS

a No. of patients in ICU (intensive care unit) (Adapted from reference 9)

Percutaneous transhepatic gallbladder aspiration (PTGBA)

PTGBA is a method to aspirate bile via the gallbladder with a small-gauge needle under ultra sonographic guidance (Fig. 2); it is an easy low-cost bedside-applicable procedure, without X-ray guidance. It has various advantages as compared with PTGBD, such as the absence of complications, including those caused by tube displacement, as it requires no drainage tube management3 and less restriction of the patient’s activity of daily living (ADL), but an RCT (level 2b)12 has indicated that the drainage is less effective (Table 2). However, as it is known that the effect of drainage is enhanced when PTGBA is performed two times or more (level 4),10,11 an RCT should be performed to confirm the effect of PTGBA by comparing it with PTGBD not only in terms of drainage but also in terms of other outcomes, including complications and the effects on patients’ ADL.

Fig. 2a–d.

Fig. 2a–d

Percutaneous transhepatic gallbladder aspiration (PTGBA) procedure. a Under ultrasound guidance, the gallbladder is punctured transhepatically by a needle with a mandolin. The mandolin is then removed. b Real-time ultrasound image: the needle tip is confirmed as a high-echoic spot in the gallbladder, revealing successful puncture under real-time ultrasound guidance. c The mandolin is removed, and bile is aspirated. d After sufficient aspiration of bile, the needle is withdrawn

Table 2.

Comparisons of results for PTGBA and PTGBD

Authors Number of patients Technical success Clinical responses Complications
Ito (2004)12 PTGBA, 28 82% 61% 0.4%
PTGBD, 30 100% 90%* 0.3%
Kutsumi (2004)10 PTGBA, 94 100% 83% (91%a) 1.1%
PTGBD, 13 100% 23.1%
Chopra (2001)3 PTGBA, 31 97% 74% 0
PTGBD, 22 97% 86% 12%*
Mizumoto (1992)11 PTGBA, 58 98% 81% (94%a) 2.5%

* P < 0.05

a PTGBA was performed twice or more

For PTGBA, considering the potential for bile leakage into the peritoneal cavity, a transhepatic puncture route is chosen, and the gallbladder contents should be completely aspirated until the gallbladder collapses, as shown by ultrasound-guided checking of the needle tip (Fig. 2).

The use of a large-gauge (18-G) needle is convenient for aspirating highly viscous bile containing inflammatory products and biliary sludge, but we should be careful to prevent bile leakage after removing the needle. While a small-gauge (21-G) needle has a lower risk of leakage after removal, aspiration of highly viscous bile is difficult with such needles and should be conducted while washing with saline containing antibiotics. Many stadies (level 2b, 4)1012 report the use of 21-G needles.

Endoscopic nasogallbladder drainage (ENGBD)

ENGBD is an external drainage procedure done by placing a 5- to 7-Fr tube, using a guide-wire technique, after selective cannulation into the gallbladder (Fig. 3). ENGBD can be used for patients with severe comorbid conditions, especially those with end-stage liver disease, in whom the percutaneous approach is difficult to perform. However, because it requires a difficult endoscopic technique, and relevant case-series studies have been conducted only at a limited number of institutions (level 4),1519 ENGBD has not been established as a standard method.

Fig. 3a–d.

Fig. 3a–d

Endoscopic nasogallbladder drainage (ENGBD) procedure.19a An endoscopic retrograde cholanglopancreatography (ERCP) catheter was inserted in the cystic duct, but the gallbladder was not visualized because of a stone impacted in the neck of the gallbladder. b Through the ERCP catheter, a hydrophilic guidewire was passed beyond the obstruction. c A radiofocus guidewire was inserted into the gallbladder. d An ENGBD catheter was inserted into the gallbladder for drainage

The Guidelines established the following grades of recommendation for gallbladder drainage, based on the currently available evidence.

Q1. What procedure should be chosen when gallbladder drainage is required in acute cholecystitis?

PTGBD: Recommendation

PTGBA: Recommendation

ENGBD: Recommendation

Discussion at the Tokyo International Consensus Meeting

PTGBD versus conservative treatment

Henry Pitt (USA): This area is an area that is obviously controversial and would be a great opportunity to do a randomized trial, a proper randomized trial of preoperative drainage followed by surgery versus surgery alone, and that is the trial that needs to be done.

Horst Neuhaus (Germany): Yes, I agree, if you consider the comment from Doctor Strasberg this morning (present state of laparoscopic cholecystectomy in America), you mentioned that in severe acute cholecystitis the incidence of complications is higher in early cholecystectomy, and therefore I also think it would be worthwhile to set up a randomized trial in these selected groups of severe acute cholecystitis.

Steven Strasberg (USA): I think an important point is when the percutaneous drainage is done. So if a patient has moderate cholecystitis and they are not going to be operated on with the most reasonable approach, we do not have the data, the most reasonable approach is to treat a patient conservatively, without percutaneous drainage, but to perform percutaneous drainage when the conservative treatment is failing. And the question is what are the criteria for failure. And they would be, local and general signs of inflammation are getting worse or they are not getting better over a period of time. So I mean, it is going to be very difficult to define those criteria at this meeting, but that is going to be the general direction of what we are going to do.

ENGBD

H. Neuhaus: So, concerning the technique I have two remarks.

The first remark is [regarding] the percutaneous route. I think we should aim at doing it via the transhepatic and not the transperitoneal route because of a high risk of complications due to drain dislocation. The second remark is [regarding] the endoscopic route (ENGBD), which was shown and reviewed by Dr. Tsuyuguchi today. Although I like endoscopy very much, I do not believe that the success rate of transcystic cannulation of the gallbladder is nearly 90% in the published literature. Because, before the era of laparoscopic cholecystostomy, we tried to insert naso-cystic catheters for dissolution of stones, and I know how difficult it is. I’m afraid that these data are from small series and are not based on an intention-to-treat analysis.

Acknowledgment

We would like to express our deep gratitude to the Japanese Society for Abdominal Emergency Medicine, the Japan Biliary Association, and the Japanese Society of Hepato-Biliary-Pancreatic Surgery, who provided us with great support and guidance in the preparation of the Guidelines. This process was conducted as part of the Project on the Preparation and Diffusion of Guidelines for the Management of Acute Cholangitis (H-15-Medicine-30), with a research subsidy for fiscal 2003 and 2004 (Integrated Research Project for Assessing Medical Technology) sponsored by the Japanese Ministry of Health, Labour, and Welfare.

We also truly appreciate the panelists who co operated with and contributed significantly to the International Consensus Meeting, held in Tokyo on April 1 and 2, 2006.

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