Abstract
Gundersen, Wenche B. (Oslo University, Oslo, Norway). New type of streptomycin resistance resulting from action of the episomelike mutator factor in Escherichia coli. J. Bacteriol. 86:510–516. 1963.—Analyses have been performed to elucidate the genetic nature of the streptomycin resistance that results from the action of the previously described episomelike mutator factor in Escherichia coli. This streptomycin resistance has been found to differ from ordinary one-step streptomycin resistance. The new type of streptomycin resistance, “mutator resistance,” can be lost, either spontaneously or by treatment with ultraviolet light and acriflavine. It is more stable in a K-12 strain than in the original E. coli strain 635. Mutator resistance segregates like a chromosomal marker in genetic crosses, and is located near the ordinary streptomycin locus. The locus for mutator resistance is distinct from that of ordinary streptomycin resistance, apparently located further toward the threonine region. Mutator resistance, unlike ordinary one-step streptomycin resistance, appears as a dominant character. The possibilities of its being a suppressor or regulator mutation are discussed.
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Selected References
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- GUNDERSEN W. B., JYSSUM K., LIE S. Genetic instability with episome-mediated transfer in Escherichia coli. J Bacteriol. 1962 Mar;83:616–623. doi: 10.1128/jb.83.3.616-623.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hashimoto K. Streptomycin Resistance in Escherichia Coli Analyzed by Transduction. Genetics. 1960 Jan;45(1):49–62. doi: 10.1093/genetics/45.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JACOB F., ADELBERG E. A. Transfert de caractéres génétiques par incorporation au facteur sexuel d'Escherichia coli. C R Hebd Seances Acad Sci. 1959 Jul 6;249(1):189–191. [PubMed] [Google Scholar]
- KIRCHNER C. E. The effects of the mutator gene on molecular changes and mutation of Salmonella typhimurium. J Mol Biol. 1960 Dec;2:331–338. doi: 10.1016/s0022-2836(60)80044-7. [DOI] [PubMed] [Google Scholar]
- LEDERBERG J. Streptomycin resistance; a genetically recessive mutation. J Bacteriol. 1951 May;61(5):549–550. doi: 10.1128/jb.61.5.549-550.1951. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miyake T. Mutator Factor in Salmonella Typhimurium. Genetics. 1960 Jan;45(1):11–14. doi: 10.1093/genetics/45.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NEWCOMBE H. B., NYHOLM M. H. The inheritance of streptomycin resistance and dependence in crosses of Escherichia coli. Genetics. 1950 Nov;35(6):603–611. doi: 10.1093/genetics/35.6.603b. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SNEATH P. H. Sex factors as episomes. Br Med Bull. 1962 Jan;18:41–45. doi: 10.1093/oxfordjournals.bmb.a069933. [DOI] [PubMed] [Google Scholar]
- Treffers H. P., Spinelli V., Belser N. O. A Factor (or Mutator Gene) Influencing Mutation Rates in Escherichia Coli. Proc Natl Acad Sci U S A. 1954 Nov;40(11):1064–1071. doi: 10.1073/pnas.40.11.1064. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATANABE T., FUKASAWA T. Episome-mediated transfer of drug resistance in Enterobacteriaceae. I. Transfer of resistance factors by conjugation. J Bacteriol. 1961 May;81:669–678. doi: 10.1128/jb.81.5.669-678.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATANABE T., FUKASAWA T. Episome-mediated transfer of drug resistance in Enterobacteriaceae. II. Elimination of resistance factors with acridine dyes. J Bacteriol. 1961 May;81:679–683. doi: 10.1128/jb.81.5.679-683.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATANABE T., WATANABE M. Transduction of streptomycin resistance in Salmonella typhimurium. J Gen Microbiol. 1959 Aug;21:16–29. doi: 10.1099/00221287-21-1-16. [DOI] [PubMed] [Google Scholar]