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. 1963 Oct;86(4):735–739. doi: 10.1128/jb.86.4.735-739.1963

ALTERATION IN TRANSFORMABILITY OF DIPLOCOCCUS PNEUMONIAE AFTER THE ACQUISITION OF GENETIC DETERMINANTS INDUCING RESISTANCE TO ERYTHROMYCIN

Francis M Sirotnak 1, Ramona B Lunt 1, Dorris J Hutchison 1
PMCID: PMC278509  PMID: 14066469

Abstract

Sirotnak, Francis M. (Sloan-Kettering Institute for Cancer Research, New York, N.Y.), Ramona B. Lunt, and Dorris J. Hutchison. Alteration in transformability of Diplococcus pneumoniae after the acquisition of genetic determinants inducing resistance to erythromycin. J. Bacteriol. 86:735–739. 1963.—The genetic alteration of a highly transformable (competent) recipient strain of Diplococcus pneumoniae by the transformation of at least two of three identified erythromycin-resistance determinants (Erya, Eryb, Eryc) results in a marked decrease (Erya-b recombinant) or complete loss (Erya-c recombinant) in the ability to be transformed. The occurrence of transformable cells in cultures of the R6 Erya-b recombinant strains, although greatly diminished, still varies during growth in a manner characteristic of the fully competent parent strain. Both Eryb and Eryc determinants appear to be linked to Erya. In experiments using P32-labeled deoxyribonucleic acid (DNA), data correlating DNA uptake with transformation show a decrease or loss in uptake capacity of the erythromycin-resistant strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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