Abstract
Okabayashi, Tadashi (Shionogi & Co., Ltd., Fukushima-ku, Osaka, Japan), Akihiro Yoshimoto, and Misao Ide. Occurrence of nucleotides in culture fluids of microorganisms. V. Excretion of adenosine cyclic 3′,5′-phosphate by Brevibacterium liquefaciens sp. n. J. Bacteriol. 86:930–936. 1963.—Brevibacterium liquefaciens sp. n., when grown in a medium containing amino acids as the nitrogen source, excreted a considerable amount of an adenine ribonucleotide, which had not previously been noticed. The nucleotide was identified as adenosine cyclic 3′,5′-phosphate by analysis, ultraviolet-absorption spectra, infrared-absorption spectra, paper chromatography, paper electrophoresis, and by comparison of behavior in hydrolysis by HCl, NaOH, and Ba(OH)2; also, behavior in digestion with a crude enzyme preparation of adenosine cyclic 3′,5′-phosphate phosphodiesterase was compared with that of an authentic sample. Preliminary examination of culture conditions revealed that, at least superficially, the substitution of dl-alanine for Casamino Acids (as nitrogen source) is one of the causes of the excretion of adenosine cyclic 3′,5′-phosphate.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- DISCHE Z., LANDSBERG E. A color reaction of pentose phosphate esters substituted in position 5. Biochim Biophys Acta. 1957 Apr;24(1):193–195. doi: 10.1016/0006-3002(57)90163-4. [DOI] [PubMed] [Google Scholar]
- DRUMMOND G. I., PERROTT-YEE S. Enzymatic hydrolysis of adenosine 3',5'-phosphoric acid. J Biol Chem. 1961 Apr;236:1126–1129. [PubMed] [Google Scholar]
- KOBATA A., KIDA M., ZIRO S. Occurrence of 3',5'-cyclic AMP in milk. J Biochem. 1961 Sep;50:275–276. doi: 10.1093/oxfordjournals.jbchem.a127444. [DOI] [PubMed] [Google Scholar]
- MANSOUR T. E., SUTHERLAND E. W., RALL T. W., BUEDING E. The effect of serotonin (5-hydroxytryptamine) on the formation of adenosine 3',5'-phosphate by tissue particles from the liver fluke, Fasciola hepatica. J Biol Chem. 1960 Feb;235:466–470. [PubMed] [Google Scholar]
- MOYED H. S., UMBARGER H. E. Regulation of biosynthetic pathways. Physiol Rev. 1962 Jul;42:444–466. doi: 10.1152/physrev.1962.42.3.444. [DOI] [PubMed] [Google Scholar]
- OKABAYASHI T., IDE M., YOSHIMOTO A. Excretion of adenosine-3',5'-phosphate in the culture broth of Brevibacterium liquefaciens. Arch Biochem Biophys. 1963 Jan;100:158–159. doi: 10.1016/0003-9861(63)90046-8. [DOI] [PubMed] [Google Scholar]
- OKABAYASHI T. Occurrence of nucleotides in culture fluids of microorganisms. III. Nucleotide excretion by Brevibacterium liquefaciens sp. n. with special reference to uridine diphospho-N-acetylglucosamine compounds. J Bacteriol. 1962 Jul;84:1–8. doi: 10.1128/jb.84.1.1-8.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RALL T. W., SUTHERLAND E. W. Adenyl cyclase. II. The enzymatically catalyzed formation of adenosine 3',5'-phosphate and inorganic pyrophosphate from adenosine triphosphate. J Biol Chem. 1962 Apr;237:1228–1232. [PubMed] [Google Scholar]
- RALL T. W., SUTHERLAND E. W. The regulatory role of adenosine-3', 5'-phosphate. Cold Spring Harb Symp Quant Biol. 1961;26:347–354. doi: 10.1101/sqb.1961.026.01.042. [DOI] [PubMed] [Google Scholar]
- SUTHERLAND E. W., RALL T. W. Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles. J Biol Chem. 1958 Jun;232(2):1077–1091. [PubMed] [Google Scholar]
- SUTHERLAND E. W., RALL T. W., MENON T. Adenyl cylase. I. Distribution, preparation, and properties. J Biol Chem. 1962 Apr;237:1220–1227. [PubMed] [Google Scholar]