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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Traffic. 2009 May 12;10(8):972–981. doi: 10.1111/j.1600-0854.2009.00927.x

Figure 2. Biosynthetic trafficking routes in polarized kidney cells.

Figure 2

The model depicts the multiple pathways used by biosynthetic cargo proteins to reach their final destinations from the TGN. Arrows indicate the paths from one organelle to the next. Specific cargo proteins that are thought to utilize each route are noted on the right. Direct routes to the apical and basolateral surface as well as a pathway via the basolateral early endosomes (BEE; pathways 1 and 2) are predicted but have not been experimentally verified. AEE, apical early endosome; ARE, apical recycling endosome; CRE, common recycling endosome. Trafficking pathways to the primary cilium are not well defined and are omitted in this model, as are the trafficking routes used by proteins not destined for the plasma membrane. Refer the text for additional details.