Table 2.
Partial list of cancer implicated genes aberrantly regulated by the HCC TR mutants.
| Gene Symbol |
Gene | Implicated Role |
|---|---|---|
| AGR2 | anterior gradient 2 homolog | cancer cell survival |
| APOL6 | apolipoprotein l, 6 | cancer cell apoptosis |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 | tumor suppressor |
| CSF1 | colony stimulating factor 1 | cancer progression |
| CX3CR1 | chemokine (c-x3-c motif) receptor 1 | cell migration/survival |
| DKK1 | dickkopf homolog 1 | tumor suppressor |
| ERRFI1 | erbb receptor feedback inhibitor 1 | tumor suppressor |
| FGF2 | fibroblast growth factor 2 | cell survival/metastasis |
| FYN | fyn oncogene related to src, fgr, yes | oncogene |
| GPC3 | glypican 3 | tumor suppressor |
| MCC | mutated in colorectal cancers | tumor suppressor |
| NR0B2 | nuclear receptor subfamily 0, group b, member 2 | tumor suppressor |
| NRCAM | neuronal cell adhesion molecule | cancer progression |
| PAK1 | p21/cdc42/rac1-activated kinase 1 | oncogene |
| PAWR | prkc, apoptosis, wt1, regulator | tumor suppressor |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | tumor suppressor |
| PTPRJ | protein tyrosine phosphatase, receptor type, j | tumor suppressor |
| SGK | serum/glucocorticoid regulated kinase 1 | oncogene |
| TIMP3 | timp metallopeptidase inhibitor 3 | tumor suppressor |
| TMEFF1 | transmembrane protein w/ egf-like and two follistatin-like domains 1 | tumor suppressor |
| VCAN | chondroitin sulfate proteoglycan 2 (versican) | metastasis |
| WT1 | wilms tumor 1 | tumor suppressor |