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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Hypertension. 2009 Oct 12;54(6):1284–1290. doi: 10.1161/HYPERTENSIONAHA.108.123570

Figure 1. Effect of epoxygenase inhibition or A2AR antagonism on systolic blood pressure (BP) of Dahl SR rats after 3 days treatment (A) and on systolic, diastolic and mean BP and heart rate on Days 1-3 of HS intake (B).

Figure 1

Dahl SR rats on NS diet were pretreated with the epoxygenase inhibitor, MS-PPOH (20 mg/Kg/day), for 3 days prior to switching rats to a HS (2% saline drinking water) intake. After 3 days of HS intake with MS-PPOH treatment, MS-PPOH was withdrawn while rats remained on HS intake for 3 more days. Rats were then switched to NS diet for 7 days. The selective A2AR antagonist, ZM 241385 (5 mg/Kg/day), was then given for 3 days prior to switching rats back to HS intake. ZM 241385 treatment continued during 3 days of HS intake. Data are expressed as means ± SEM; n = 6-7; * p<0.05, ** p<0.005, *** p<0.001 vs. NS; # p<0.05, ## p<0.005, ### p<0.001 vs. control on each day. Note scale differences.