Abstract
Brightman, Vernon (The University of Chicago, Chicago), and William R. Martin. Pathway for the dissimilation of itaconic and mesaconic acids. J. Bacteriol. 82:376–382. 1961.—Studies on the oxidation of itaconic and mesaconic acids by a Pseudomonas sp., adapted to utilize either of these acids as a sole carbon source, have provided evidence for a pathway converting both itaconate and mesaconate to succinate. A metabolic interconversion of itaconate, mesaconate, and citramalate has also been demonstrated by whole cell and cell-free enzyme studies.
Succinate derived from methylene-labeled itaconate was found to be labeled in the inside carbon atoms, a fact which indicates that the branched chain compound was converted into a straight chain molecule by a shift of the methylene carbon (C-5) from the side chain of itaconate to a position between C-2 and C-3 in an, as yet, unknown straight chain intermediate prior to its conversion to succinate.
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Selected References
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- ADLER J., WANG S. F., LARDY H. A. The metabolism of itaconic acid by liver mitochondria. J Biol Chem. 1957 Dec;229(2):865–879. [PubMed] [Google Scholar]
- ARPAI J. Itaconicoxidase: an enzyme from an ultraviolet-induced mutant of Aspergillus terreus. Nature. 1958 Sep 6;182(4636):661–662. doi: 10.1038/182661a0. [DOI] [PubMed] [Google Scholar]
- BENTLEY R., THIESSEN C. P. Biosynthesis of itaconic acid in Aspergillus terreus. I. Tracer studies with C14-labeled substrates. J Biol Chem. 1957 Jun;226(2):673–687. [PubMed] [Google Scholar]
- BESSMAN S. P., ROSSEN J., LAYNE E. C. Gamma-Aminobutyric acid-glutamic acid transamination in brain. J Biol Chem. 1953 Mar;201(1):385–391. [PubMed] [Google Scholar]
- Barker H. A., Weissbach H., Smyth R. D. A COENZYME CONTAINING PSEUDOVITAMIN B(12). Proc Natl Acad Sci U S A. 1958 Nov 15;44(11):1093–1097. doi: 10.1073/pnas.44.11.1093. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Buston H. W. Note on the isolation of mesaconic acid from cabbage leaves. Biochem J. 1928;22(6):1523–1525. doi: 10.1042/bj0221523. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HASKINS R. H., THORN J. A., BOOTHROYD B. Biochemistry of the Ustilaginales. XI. Metabolic products of Ustilago zeae in submerged culture. Can J Microbiol. 1955 Dec;1(9):749–756. doi: 10.1139/m55-089. [DOI] [PubMed] [Google Scholar]
- ISENBERG H. D., SEIFTER E., BERKMAN J. I. The interrelationships of vitamin B12, beta-methylaspartate and thymine. Biochim Biophys Acta. 1960 Mar 25;39:187–189. doi: 10.1016/0006-3002(60)90150-5. [DOI] [PubMed] [Google Scholar]
- MUNCH-PETERSEN A., BARKER H. A. The origin of the methyl group in mesaconate formed from glutamate by extracts of Clostridium tetanomorphum. J Biol Chem. 1958 Feb;230(2):649–653. [PubMed] [Google Scholar]
- STADTMAN E. R., BARKER H. A. Fatty acid synthesis by enzyme preparations of Clostridium kluyveri. VI. Reactions of acyl phosphates. J Biol Chem. 1950 Jun;184(2):769–793. [PubMed] [Google Scholar]
- WANG S. F., ADLER J., LARDY H. A. The pathway of itaconate metabolism by liver mitochondria. J Biol Chem. 1961 Jan;236:26–30. [PubMed] [Google Scholar]