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. 1962 May;83(5):1017–1024. doi: 10.1128/jb.83.5.1017-1024.1962

IN VITRO EFFECTS OF C-REACTIVE PROTEIN ON PHAGOCYTOSIS

Y Hokama a, Monroe K Coleman a, Richard F Riley a
PMCID: PMC279402  PMID: 13908279

Abstract

Hokama, Y. (University of California, Los Angeles), Monroe K. Coleman, and Richard F. Riley. In vitro effects of C-reactive protein on phagocytosis. J. Bacteriol. 83:1017–1024. 1962. Carbonyl iron spherules, Diplococcus pneumoniae types IIs and XXVIIs, and Serratia marcescens were phagocytosed more rapidly and in greater numbers by leukocytes of normal human blood after incubation with C-reactive protein. With the exception of carbonyl iron spherules, addition of C-reactive protein to whole blood containing substrate had little effect on the extent of phagocytosis. Normal and acute-phase seromucoid Escherichia coli lipopolysaccharide and crude endogenous pyrogen were without a stimulating effect under the same conditions in the homologous systems employed.

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Selected References

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  1. CASSEN B., HITT J., HAYS E. F. The efficient separation of lymphocytes from normal human blood. J Lab Clin Med. 1958 Nov;52(5):778–783. [PubMed] [Google Scholar]
  2. COHN Z. A., MORSE S. I. Functional and metabolic properties of polymorphonuclear leucocytes. II. The influence of a lipopolysaccharide endotoxin. J Exp Med. 1960 May 1;111:689–704. doi: 10.1084/jem.111.5.689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FRITZE E., WENDT F. Zum Wirkungsmechanismus bakterieller Lipopolysaccharide. II. Die Phagocytoseaktivität menschlicher Blutgranulocyten unter dem Einfluss bakterieller Lipopolysaccharide in vitro. Klin Wochenschr. 1955 Jun 15;33(23-24):575–576. doi: 10.1007/BF01473769. [DOI] [PubMed] [Google Scholar]
  4. HOKAMA Y., COLEMAN M. K., RILEY R. F. Cx-Reactive protein response in rabbits during immunization with foreign proteins. J Immunol. 1960 Jul;85:72–77. [PubMed] [Google Scholar]
  5. MONTELLA S., WOOD H. F. Studies on the Cx-reactive protein. II. Inhibition of the Cx-reactive protein response in rabbits by blockade of the reticulo-endothelial system. J Exp Med. 1957 Aug 1;106(2):321–326. doi: 10.1084/jem.106.2.321. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. PETERSDORF R. G., RIBBLE J. L., SHULMAN J. A. Absorption of endogenous pyrogens by bentonite. Proc Soc Exp Biol Med. 1961 Jan;106:234–237. doi: 10.3181/00379727-106-26297. [DOI] [PubMed] [Google Scholar]
  7. RILEY R. F., HOKAMA Y. Appearance of a substance in acute phase serum which elicits Cx-protein responses. Science. 1960 Dec 23;132(3443):1894–1895. doi: 10.1126/science.132.3443.1894. [DOI] [PubMed] [Google Scholar]
  8. ROWLEY D. The role of opsonins in non-specific immunity. J Exp Med. 1960 Jan 1;111:137–144. doi: 10.1084/jem.111.1.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. SELMAN D., HALPERN A. Pitfalls in the determination of C-reactive protein, an acute-phase reactant. Angiology. 1956 Jun;7(3):292–304. doi: 10.1177/000331975600700310. [DOI] [PubMed] [Google Scholar]
  10. WOOD H. F. Effect of C-reactive protein on normal human leukocytes. Proc Soc Exp Biol Med. 1951 Apr;76(4):843–847. doi: 10.3181/00379727-76-18650. [DOI] [PubMed] [Google Scholar]
  11. WOOD H. F. The relationship between the acute phase response and antibody production in the rabbit. I. Correlation between the early appearance of Cx-reaction protein and subsequent antibody production. J Exp Med. 1953 Oct;98(4):311–319. doi: 10.1084/jem.98.4.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Winzler R. J., Devor A. W., Mehl J. W., Smyth I. M. STUDIES ON THE MUCOPROTEINS OF HUMAN PLASMA. I. DETERMINATION AND ISOLATION. J Clin Invest. 1948 Sep;27(5):609–616. doi: 10.1172/JCI102006. [DOI] [PMC free article] [PubMed] [Google Scholar]

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